[tt] Next Big Future - 3 new articles
Eugen Leitl
<eugen at leitl.org> on
Sun Jan 4 19:36:07 CET 2009
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Subject: Next Big Future - 3 new articles
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Here are the latest updates for eugen at leitl.org
"[2]Next Big Future" - 3 new articles
1. [3]Carnival of Space Week 85
2. [4]Novacem Making CO2 absorbing cement and Could Eventually Absorb
up to 6 trillion tons of CO2
3. [5]Nutrigenomics and life extension
4. [6]More Recent Articles
5. [7]Search Next Big Future
[8]Carnival of Space Week 85
[9]Carnival of Space week 85 is up at Cheap Astronomy.
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[16]This site provided information on space elevator tether strength
requirements and development status
[17]Centauri Dreams looks at interstellar mission possibilities.
A longbet was made: the first true interstellar mission, targeted at
the closest star to the Sun or even farther, will be launched before
or on 6 December 2025, and will be widely supported by the public.
True side of the bet: [18]Tibor Pacher of Perefrinus Interstellar
False side of the bet: Centauri Dreams
[19]Tibor of Pergrinus Interstellar makes his case.
One of the mission specs was a flight time of 2000 years or less to
the star of choice. Assuming this is Proxima Centauri simply
because of its, well, proximity, we arrive at a minimum average
mission velocity of about 650 kilometers per second. That can be
compared to Voyager 1's 17.1 km/s to get an idea of the upgrade in
velocity needed, but as we've noted in these pages before, the
right kind of sail employing a Sun-diver maneuver might get at
least close to that speed.
Useful data along the way? Tibor names the targets of opportunity:
A craft traveling at 650 km/s gets out to the Kuiper Belt in about
a year and reaches the heliosheath at 100 AU. Year two takes it out
of the heliosphere entirely, while years five to ten are of note
because they take us to the distance of the Sun's gravitational
focus, where Sol acts as a unique lens to magnify distant
starlight. Recall that unlike optical lenses (where the light
diverges after the focus), a gravitational lens has a focal line
that extends to infinity. In other words, separations greater than
550 AU (where the gravitational lensing effect is first available)
still offer unique observational possibilities.
Beyond 550 AU, the electromagnetic radiation from the occulted
object under study is amplified by a factor of 10**8 (100 million
times). The 'spot radius' (distance from the centre line of the
image at which the image intensity gain falls by a factor of 4) has
been calculated...to be about 11 km for a Sun-spacecraft separation
of 2,200 AU.
IFRAME:
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Somewhere around year 20 of the Pacher probe's mission it reaches
the Oort Cloud, an area of obvious interest that may, in fact,
extend halfway to the target star. We might also mention the
Pioneer anomaly, for an outbound Proxima Centauri probe can
obviously be studied in terms of anomalous acceleration along its
route. Two thousand years after launch, the probe reaches the
Proxima Centauri system, but for those who object that surely
faster probes would have passed it along the way, I can only agree
with Tibor that such a probe would get much done along its route
before that happens, given a properly configured mission.
[21]Free Space at Discovery.com has an interview with Elon Musk of
SpaceX
SpaceX and Orbital Sciences got a NASA contract for $3.5 billion to
deliver stuff to the International Space Station. SpaceX's share,
totaling $1.6 B to start, covered 12 missions, while Orbital, which
got an additional $300 million, was responsible for eight.
Elon: The difference is bigger than even the number of launches
because our Dragon spacecraft has 50 percent more payload
capability than Orbital. It's actually, if you were to multiple it
out, it's as if we were doing 18 launches and they were doing eight
launches.
[22]21st Century Waves looks at an MIT study of the future of human
spaceflight
MIT recommends that the International Space Station should be used
by the U.S. and its international partners through 2020 to support
human spaceflight to Mars. The Bush Vision of Moon exploration
should be clarified and expanded so that it is "more, and not less
ambitious."
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[39]Novacem Making CO2 absorbing cement and Could Eventually Absorb up to 6
trillion tons of CO2
[40]The UK Guardian reports on Novacem, a company that is making
cement from magnesium silicates that absorbs more CO2 as it hardens.
Normally cement adds a net 0.4 tons of CO2 per ton of cement, but this
new cement would remove 0.6 tons of CO2 from the air. This is
competitive with the claims of [41]Calera cement.
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[48]Novacem's cement, based on magnesium silicates, not only
requires much less heating, it also absorbs large amounts of CO2 as
it hardens, making it carbon negative. Set up by Vlasopoulos and
his colleagues at Imperial College London, Novacem has already
attracted the attention of major construction companies such as Rio
Tinto Minerals, WSP Group and Laing O'Rourke, and investors
including the Carbon Trust.
The company has just started a £1.5m project funded by the
government-backed Technology Strategy Board to build a pilot plant.
If all goes well, Vlasopoulos expects to have Novacem products on
the market within five years.
Vlasopoulos responded that magnesium silicates are abundant
worldwide, with 10,000 billion tonnes available, according to some
estimates. "In addition, the production process of our cement is of
a chemical nature, which means it can also utilise various
industrial byproducts containing magnesium in its composition." He
is confident the material will be strong enough for use in
buildings but acknowledged that getting licenses to use it will
take several years of testing.
Standard cement, also known as Portland cement, is made by heating
limestone or clay to around 1,500C. The processing of the
ingredients releases 0.8 tonnes of CO2 per tonne of cement. When it
is eventually mixed with water for use in a building, each tonne of
cement can absorb up to 0.4 tonnes of CO2, but that still leaves an
overall carbon footprint per tonne of 0.4 tonnes.
Novacem's cement, which has a patent pending on it, uses magnesium
silicates which emit no CO2 when heated. Its production process
also runs at much lower temperatures - around 650C. This leads to
total CO2 emissions of up to 0.5 tonnes of CO2 per tonne of cement
produced. But the Novacem cement formula absorb far more CO2 as it
hardens - about 1.1 tonnes. So the overall carbon footprint is
negative - ie the cement removes 0.6 tonnes of CO2 per tonne used.
IFRAME:
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0.6 tonnes times 10 trillion tons is 6 trillion tons. The amount of
CO2 generated by people is 27 billion tons worldwide and this could
increase to 45 billion tons. So 6 trillion tons is about 200 years
worth of CO2 storage.
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[66]Nutrigenomics and life extension
[67]Nutrigenomics is the study of molecular relationships between
nutrition and the response of genes, with the aim of extrapolating
how such subtle changes can affect human health. Nutrigenomics
focuses on the effect of nutrients on the genome, proteome, and
metabolome. By determining the mechanism of the effects of
nutrients or the effects of a nutritional regime, Nutrigenomics
tries to define the relationship between these specific nutrients
and specific nutrient regimes (diets) on human health.
Nutrigenomics has been associated with the idea of personalized
nutrition based on genotype. There is hope that nutrigenomics will
ultimately enable such personalised dietary advice.
A mainstream belief is that the impact over the next ten years on
public health will be minor.
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[74]OMICS: A Journal of Integrative Biology has a free issue on
Nutrigenomics.
The expectations from nutrigenomics science are substantial. An
important promise of nutrigenomics stems from its strong focus on
public health and prevention/modification of "pre-disease
phenotypes" in apparently healthy individuals. This coincides with
a recent shift in emphasis in the biosciences toward treatment of
future disease susceptibilities (i.e., preemptive medicine) rather
than alleviation of established disease (Ozdemir and Godard, 2007b;
Rose, 2006). Thus, in contrast to previous applications of genomics
technologies where the goal is to distinguish existing disease from
absence of disease, nutrigenomics aims to discern nuanced
differences in predisease states such that personalized dietary
interventions can be designed to prevent or modify future disease
susceptibility.
[75]Gregory Benford talks about the potential of nutrigenomics in his
answer to the 2009 Edge question " What will change everything?"
Benford answers people living to 150 years or more.
Knowledge comes first, then its use. Science yields engineering.
Already there seems no fundamental reason why we cannot live to 150
years or longer. After all, nature has done quite well on her own.
We know of a 4,800-year-old bristlecone pine, a 400 year old
clam--plus whales, a tortoise and koi fish over 200 years old--all
without technology. After all, these organisms use pathways we
share, and can now understand.
It will take decades to find the many ways of acting on the
longevity genes we already know. Nature spent several billion years
developing these pathways; we must plumb them with smart modern
tools. The technology emerging now acts on these basic pathways to
immediately effect all types of organs. Traditionally, medicine
focuses on disease by isolating and studying organs. Fair enough,
for then. Now it is better to focus on entire organisms. Only
genomics can do this. It looks at the entire picture.
Quite soon, simple pills containing designer supplements will
target our most common disorders -- cardiovascular, diabetes,
neurological. Beyond that, the era of affordable, personal genomics
makes possible designer supplements, now called neutrigenomics.
Tailored to each personal genome, these can enforce the repair
mechanisms and augmentations that nature herself provided to the
genomically fortunate.
So...what if it works?
IFRAME:
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[77]Gregory Benford's company is Genescient
[78]A science primer is provided at the Genescient site
Using our 100 proprietary longevity gene pathways, combined with
the public data on human gene dysfunction associated with
age-related disease, we have identified Designer Therapeutics for
the genetic pathways controlling aging. In selecting compounds to
test, we search the published literature for compounds that act on
one or more of our proprietary genetic pathways of aging.
Genescient has sophisticated software that cross links gene
function in Drosophila with possible human therapeutics for
age-related diseases. Drosophila is an excellent model system of
aging and age-related disease that has many genetic pathways that
are highly conserved in humans. Therefore, therapeutic substances
that act on genetic pathways in Drosophila often work similarly in
humans.
The speed and efficacy of our Drosophila testing allows us to test
various combinations of compounds to acquire a highly synergistic
set of compounds that act through differing aging pathways. This
adds greatly to the therapeutic efficacy of the final treatment.
Slowing the aging process requires several compounds, acting on
several genetic pathways simultaneously. Our screening procedure
allows us to identify quickly the best combinations of compounds
that can act simultaneously on multiple genetic networks
(cardiovascular, metabolic, neurological, etc).
When we find a multipath set of therapeutic compounds, we then do
final nutrigenomic testing in humans. We establish dosage levels by
prior literature data and our own testing. Once a group of 3 to 4
nutrigenomic compounds has been identified as synergistic in
Drosophila, we can evaluate therapeutic efficacy of the
nutrigenomic combination in humans using clinical tests such as:
athletic performance, cognitive performance, lung capacity, skin
elasticity, blood lipids, serum glucose, as well as inflammatory
markers like CRP and IL-6. For any particular age-related disease,
our proprietary therapeutic compounds could also be tested in
specific disease mouse models or in human clinical trials.
Genescient's Designer Therapeutics fine tune the body's gene
expression to mimic genetically selected longevity and reduced all
cause mortality. This approach is in marked contrast to competing
Pharma and biotech companies that focus on a single age-related
disease or disorder. Genescient is the first company to develop
genetic Designer Therapeutics to delay aging and the age-related
diseases.
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78. http://www.feedblitz.com/t.asp?/64651/2987253/http://genescient.com/documents/science_primer.html
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80. http://feeds.feedburner.com/~f/blogspot/advancednano?a=tIj2D4.P
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98. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/496373412/sasol-making-11-million-barrel-per-day.html
99. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/495862316/dnabiotechsynthetic-biology.html
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102. http://www.feedblitz.com/f/f.fbz?Subscriptions=64651
103. http://www.feedblitz.com/f
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105. http://www.feedblitz.com/
106. http://www.feedblitz.com/
----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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