[tt] Next Big Future - 3 new articles
Eugen Leitl
<eugen at leitl.org> on
Thu Jul 24 10:26:02 UTC 2008
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Date: Sat, 19 Jul 2008 02:33:30 -0400
To: eugen <eugen at leitl.org>
Subject: Next Big Future - 3 new articles
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"[2]Next Big Future" - 3 new articles
1. [3]Latest on life extension and combating Alzheimers
2. [4]Carnival of Space Week 63
3. [5]Graphene is the strongest material ever
4. [6]More Recent Articles
5. [7]Search Next Big Future
[8]Latest on life extension and combating Alzheimers
[9]An ambitious plan to sequence 100 genes in 1,000 healthy old people
could shed light on genetic variations that insulate some people from
the ailments of aging, including heart disease, cancer, and diabetes,
allowing them to live a healthy life into their eighties and beyond.
Rather than focusing on genetic variations that increase risk for
disease, scientists plan to focus on genes that have previously been
linked to health and longevity.
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Researchers are collecting blood samples from 1,000 people age 80
or older who have never suffered any serious illnesses and do not
take medication.
Topol and his collaborators will compare the gene sequences from
the healthy volunteers with DNA samples collected from people who
died from age-related diseases before they reached their eighties.
The scientists have already found that the healthy people had only
a slightly lower probability of carrying disease-linked variations.
That supports the idea that protective genes are playing a major
role in people's successful aging.
Scientists hope that identifying the molecular basis for this
protective effect will enable them to mimic it with drugs.
Success could mean that everyone who received the right treatments
could live healthy lives into their eighties. Life expectancy could
approach or exceed 100 when combined with [16]new detection and
[17]treatments for cancer and [18]calorie restriction mimicking drugs
[19]Gene therapy was used to improve the function of genetically
damaged vision, which shows that it is possible protective life
extension genes could also be modified in adults.
[20]Gene silencing is getting more effective and [21]gene therapy is
getting cheaper, safer and more effective
[22]A Russian antihistamine drug, Dimebon, reverses cognitive decline
in Alzheimer's patients over a 12 month period in early human testing
This is huge because other drugs just slow the decline to varying
degrees. It is also big because they believe the medication works by
stabilizing mitochondria which is an important factor in aging (One of
the seven aging damage targets of SENS).
[23]H/T to Al fin
"What we saw in the clinical trial is that people on the medication
continued to improve over time," Doody said. "Those on placebo
continued to decline."
Researchers believe the medication works by stabilizing
mitochondria, the cellular components that produce energy, and
possibly by inhibiting brain cell death. Researchers evaluated
patients' thinking and memory ability, overall function,
psychiatric and behavioral symptoms, and ability to perform daily
activities.
"Usually at this point in a drug's development, we are happy to see
improvement in one of the outcome measures," Doody said. "We saw
improvement in all five."
Some participants complained of occasional dry mouth, but no one
opted out of the study because of the side effects.
"As we continue research, we hope to replicate these results,"
Doody said. "My belief is that this drug will turn out to be useful
for Alzheimer's disease, regardless of the stage of the disease."
The positive effects of maintaining and improving mitochondria
function shows the validity of the [24]SENS approach to life
extension.
[25]Mitosens is one of the seven parts of the SENS approach.
Success in all seven parts of SENS to repair the damage of aging
before they become disease. This repair is [26]applying rejuvenation
to a body.
FURTHER READING
[27]The full alzheimer's paper on Dimebon is online and requires free
registration to access at the Lancet.
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[45]Carnival of Space Week 63
[46]Angry Astronomer is hosting the Carnival of Space week 63.
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[53]This site supplied the Carnival with the new capabilities that we
have to reduce and reverse the Casimir force which could lead to
breakthrough space propulsion and being able to tap Zero Point Energy
[54]Babe in the Universe discusses the recent discovery of water on
the moon.
[55]Stars With a Bang talks about how humans could potentially travel
to and colonize new solar systems if we end up making our own
inhospitable.
Check out [56]the Carnival of Space week 63 for much more.
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[74]Graphene is the strongest material ever
[75]A new and highly reliable approach for making graphene membranes
of a macroscopic size (currently up to 100 µm in diameter) provided a
lot fo graphene samples for strength tests Such measurements had never
been taken before because they must be performed on perfect samples of
graphene, with no tears or missing atoms.
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Graphene transistors could take the heat of being very high
performance computer processors. Graphene would make durable,
mechanically operated electrical switch for communications devices
including cell phones and advanced radar.
[82]James Hone, mechanical-engineering professors at Columbia
University, compares his material strength test to stretching a piece
of plastic wrap over the top of a coffee cup, and measuring the force
that it takes to puncture it with a pencil. If he could get a large
enough piece of the material to lay over the top of a coffee cup, he
says, graphene would be strong enough to support the weight of a car
balanced atop the pencil.
[83]New Scientist magazine indicates that the graphene could be pushed
downwards by 100 nanometres with a force of up to 2.9 micronewtons
before rupturing. The researchers estimate that graphene has a
breaking strength of 55 newtons per metre.
"As a way of visualising the force needed to break the membranes,
imagine trying to puncture a sheet of graphene that is as thick as
ordinary plastic food wrap - typically 100 micrometers thick," says
James Hone, head of the laboratory at Columbia in which Lee
studies. "It would require a force of over 20,000 newtons,
equivalent to the weight of a 2000 kilogram car."
That strength puts graphene literally "off the chart" of the
strongest materials measured, Hone says. "These measurements
constitute a benchmark of strength that a macroscopic system will
never achieve, but can hope to approach," he says.
In separate work, Tim Booth and Peter Blake at the University of
Manchester, UK, are well on the way to bringing atomically perfect
graphene out of the nanoscopic and into to the macroscopic world.
Their team has patented a new method to produce free-standing
graphene flakes up to 100 micrometers in diameter.
Booth and Blake have realised that acrylic glass (PMMA) has the
same optical properties as silicon and can also highlight graphene
flakes. It however easily dissolves away in acetone, a less
aggressive chemical that doesn't alter graphene. Using their
technique, Booth and Blake can easily isolate large crystals.
We are limited only by the size of graphene flakes available," says
Booth. "There is no reason that the method will not scale up to
much larger flakes."
Using these flakes, Booth and Blake have also found that graphene
is extraordinarily stiff. A crystal supported on just one side
extends nearly 10 micrometers without any support - equivalent to
an unsupported sheet of paper 100 metres in length. It had
previously been assumed that graphene would curl up if left
unsupported.
Graphene could be added to polymers to form super-strength
composites, Booth says. "However, it is likely the most interesting
applications will result from a unique combination of graphene's
properties: transparency, electronic structure, stiffness, thermal
conductivity," he says. "That could help achieve science-fiction
applications."
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73. LYNXIMGMAP:file://localhost/tmp/mutt.0iJ3AH.html#outbrainMap_64651_1
74. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/339215925/graphene-is-strongest-material-ever.html
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81. http://www.feedblitz.com/adfaq.asp
82. http://www.feedblitz.com/t.asp?/64651/2987253/http://www.technologyreview.com/Nanotech/21098/?a=f
83. http://www.feedblitz.com/t.asp?/64651/2987253/http://technology.newscientist.com/article/dn14354-atomthick-carbon-sheets-set-new-strength-record.html?DCMP=ILC-hmts&nsref=news7_head_dn14354
84. http://feeds.feedburner.com/~a/blogspot/advancednano?a=H8AMmw
85. http://feeds.feedburner.com/~f/blogspot/advancednano?a=O05ySJ
86. http://feeds.feedburner.com/~f/blogspot/advancednano?a=dfsl3J
87. http://feeds.feedburner.com/~f/blogspot/advancednano?a=Ys1NJJ
88. http://feeds.feedburner.com/~f/blogspot/advancednano?a=pFE6yj
89. http://feeds.feedburner.com/~f/blogspot/advancednano?a=sZicPj
90. http://feeds.feedburner.com/~f/blogspot/advancednano?a=qHfCkj
91. http://feeds.feedburner.com/~f/blogspot/advancednano?a=GQaLaJ
92. http://feeds.feedburner.com/~f/blogspot/advancednano?a=lzElhj
93. http://feeds.feedburner.com/~f/blogspot/advancednano?a=qDMh0J
94. http://feeds.feedburner.com/~f/blogspot/advancednano?a=htmm7j
95. http://feeds.feedburner.com/~f/blogspot/advancednano?a=cRiDSJ
96. http://www.feedblitz.com/f/f.fbz?Fwd2FriendEdit=64651;171888;http://feeds.feedburner.com/~r/blogspot/advancednano/~3/339215925/graphene-is-strongest-material-ever.html;Graphene%20is%20the%20strongest%20material%20ever;254879
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100. LYNXIMGMAP:file://localhost/tmp/mutt.0iJ3AH.html#outbrainMap_64651_2
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102. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/338208768/195k-superconductor-at-dry-ice.html
103. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/337459825/3-billion-super-soldier-program-10.html
104. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/337327782/safe-human-enhancement-of-strength.html
105. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/336264947/long-carbon-nanotubes-and-other-us-army.html
106. http://tagline.feedblitz.com/nfc?affid=10059&sender=cf515ead64587146fb6815a2a013d226,feedblitz.com&rcpt=8da0e5c5ebdabb2bd85a8a5d3a603a7c,leitl.org&ranstr=98e27797-555c-11dd-9626-003005ce&group=64651
107. http://www.feedblitz.com/adfaq.asp
108. http://www.feedblitz.com/f/f.fbz?EmailRemove=_Mjk4NzI1M3w2NDY1MXxldWdlbkBsZWl0bC5vcmd8MjU0ODc5_
109. http://www.feedblitz.com/f/f.fbz?Subscriptions=64651
110. http://www.feedblitz.com/f
111. http://www.feedblitz.com/f/f.fbz?EmailRemove=_Mjk4NzI1M3x8ZXVnZW5AbGVpdGwub3JnfDI1NDg3OQ==_
112. http://www.feedblitz.com/
113. http://www.feedblitz.com/
----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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