[tt] Next Big Future - 2 new articles
Eugen Leitl
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Mon Jul 21 13:37:35 UTC 2008
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Subject: Next Big Future - 2 new articles
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"[2]Next Big Future" - 2 new articles
1. [3]$3 billion super soldier program: 10 times muscle endurance, 7
foot vertical leap, wall crawling, personal flight and more
2. [4]Safe Human enhancement of strength, speed, endurance, cognition
and reducing aging effects and reducing obesity
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[7]$3 billion super soldier program: 10 times muscle endurance, 7 foot
vertical leap, wall crawling, personal flight and more
DARPA today has a long-term, $3 billion program to help make such a
"Metabolically Dominant Soldier." In other words, the military is
studying how to use technology and biology to meld man and machine and
transcend the limits of the human body. Described the project
director, [8]"My measure of success is that the International Olympic
Committee bans everything we do" The $3 billion program is definitely
trying to achieve transhuman performance goals.
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The wearable gear would enable running at 100 meter olympic sprinter
speed for hours and the 7 foot vertical leap, the wall crawling,
personal flight, invisibility, greatly enhanced strength, better body
armor and carrying bigger and more powerful weapons.
The drugs and genetic enhancements and some technology which gets
applied would allow for regeneration, faster healing, muscle strength
enhancement up to current olympic levels, endurance of an Alaskan sled
dog, cognitive enhancement, operate without sleep for many days
without performance degradation, the metabolic energy of twenty year
old for a forty or fifty year old and immunity to pain.
The Metabolically Dominant Soldier program is managed by Joe
Bielitzki. He is talking about fixing your cells so that you could
live off your fat. Bielitzki acknowledges the potential for spin-off
technologies. "Forty billion dollars a year goes into the weight loss
industry in this country," he muses. "This will change it."
Regeneration, better healing, better immune systems would all
revolutionize healthcare costs and healthcare effectiveness. So
trillions in economic benefit as a side effect of supersoldier
success. DARPA is also trying to enhance cognition, training and
giving the energy levels of youth to the elderly. Those could provide
multi-billion or even trillion dollar per year boosts to the US and
world economy.
Projects in pipeline range from drugs that will boost muscles and
energy by a factor of 10, akin to steroids...on steroids (the project
is jokingly termed the "Energizer Bunny in Fatigues") to wearable,
cooling gloves that regulate body temperature and prevent soldiers
from getting overheated (and thus tired) even on the hottest desert
day. [Keeping the body cool increases endurance]
[15]This program is going well beyond some current relatively safe and
conservative forms of performance enhancement. [Safer SARM/steroids,
endurance enhancing drink]
A major focus is on helping the soldier's body to better deal with
trauma and damage. One such is the "pain vaccines" coming out of a
program at Rinat Neuroscience [Pfizer acquired [16]Rinat Neuroscience
in 2006]. Researchers are hopeful these "will block the sense of pain
for almost a month," describes DARPA's Michael Goldblatt.
[17]The substance does is block intense pain in less than 10 seconds.
Its effects last for 30 days. It doesn't stifle your reactions. If you
touch a hot stove, you still have the initial shock; your hand will
still automatically jerk away. But after that, the torment is gone.
The product works on the inflammatory response that is responsible for
the majority of subacute pain. If you get shot, you feel the bullet,
but after that, the inflammation and swelling that trigger agony are
substantially reduced. The company has already hit its first
milestones in animal testing and is preparing reports for scientific
conferences.
[18]Army Soldier enhancement systems
The plan is for new body armor that, instead of Kevlar, is filled with
nano-materials that are connected to a computer. [Computer controlled
liquid armor] It would normally be as flexible as regular uniform made
of fabric. But, like how a crash-bag works inside a car, it would
activate whenever the system detects a bullet strike and turn as hard
as steel in an instant.
Gloves could turn into real-life brass knuckles.
The fabric could even be woven in with "nanomuscle fibers" that
simulate real muscles, giving soldiers more an estimated "25 to 35
percent better lifting capability." So myostatin strength boost to get
to olympic athlete strength levels and then 25-35% boost from a soft
suit. Use better exoskeletons for more strength enhancement.
From deflecting bullets to powers of invisibility, as military analyst
Max Boot writes, such a suit truly "would give ordinary mortals many
of the attributes of comic book superheroes.
Our wimpy little Achilles tendons allow the average human to run
somewhere between 6 to 8 miles an hour and, unless your name is LeBron
James, leap only a few feet in the air. New "bionic boots" and "spring
walkers" in development are hoped to solve this. These attach outside
the leg and mechanically mimic the enlarged Achilles tendon of a
kangaroo, one day perhaps giving the wearer the ability to run as fast
as 25 miles per hour and leap 7 feet.
The "Z-Man project." [19]Creating gecko inspired gloves and boots for
wall crawling.
Robotic gecko demonstrator
[20]Exoskeleton flying vehicle with a maximum speed of maximum Speed
113 mph, range of 184 miles and endurance of endurance 2.2+ hours.
[21]The Mesoscopic Integrated Conformal Electronics (MICE) program has
already succeeded in printing electronic circuits on the frames of
eyeglasses and helmets, weaving them into clothes, even putting them
on insects. These include electronics, antennas, fuel cells, batteries
and solar cells.
The Biological Input/Output Systems program is designed to enable
plants, microbes and small animals to serve as "remote sentinels for
reporting the presence of chemical or biological" particles. They'd do
this by changing color, lighting up fluorescently, dropping their
leaves or changing the color of their flowers.
The Brain-Machine Interface program is investigating how you would put
wireless modems into people's skulls.
And that's just the Defense Sciences Office, the department of DARPA
most directly involved with human enhancement. Meanwhile, on the floor
where the Information Processing Technology Office (IPTO) resides, its
director, Ron Brachman, former research vice president at AT&T Labs
and previously at Bell Labs, and president of the American Association
for Artificial Intelligence, wants to complete DARPA's vision from the
sixties. When the original IPTO was created in 1962, its director,
J.C.R. Licklider, focused the office on his novel conception of
computers and humans working in symbiosis. That idea resulted in the
Internet. Now the new IPTO "wants to realize this vision by giving
computing systems unprecedented abilities to reason, to learn, to
explain, to accept advice, and to reflect, in order to finally create
systems able to cope robustly with unforeseen circumstances,"
according to Brachman. The object of the game is to produce
machines--and the italics are his--"that truly know what they're
doing.
[22]A project is regarded as "DARPA-esque" only if few others would
tackle it, but it would be earth-jolting if it did work. [23]DARPA's
attitude is if an idea looks like a sure thing, let somebody else fund
it. [24]The "special focus area" is for really extreme projects.
FURTHER READING
[25]Darpa supports the Raytheon Sarcos XOS exoskeleton
Of the three teams that took part in a seven year $75 million
project (Sarcos, Oak Ridge National Laboratory, and the University
of California at Berkeley), the XOS emerged in 2005 as the suit
closest to the agency's initial vision. It is the only full
exoskeleton the military has moved into the next development stage;
[26]Sarcos is now working under a two-year, $10-million Army grant.
During XOS demos the suit is tethered to a hydraulic pump that
draws electricity from an external power supply. The suit can
operate from batteries, but only for 40 minutes at a time.
The country's other two top exoskeleton designers, Massachusetts
Institute of Technology professor Hugh Herr and Homayoon Kazerooni
of the University of California at Berkeley, began with the power
problem.
Herr is trying to build a leg-powering machine that uses as little
energy as possible--the first iteration draws a mere two watts,
comparable to a portable radio--but can support 80 percent of an
80-pound load on a user's back. Herr thinks that within the near
future, he can improve the mechanics so that the machine actually
saves the wearer effort.
Kazerooni has made the Human Load Carrier (HULC) which is a
lower-body exoskeleton that can operate for more than 20 hours
without recharging. He says it allows the user to carry 100 pounds
on his back and burn 15 percent less oxygen than if he was
supporting the added weight alone. A three-year, $2-million grant
from the National Institute of Standards and Technology is being
used to modify as a wheelchair replacement.
[27]The army is now performing live fire tests of new body armor
Currently : the Army issued the Improved Outer Tactical Vest, a
redesigned version of Interceptor body armor, starting in late 2006.
The soft body armor protects against 9mm ammunition and fragmentation.
IOTV is also equipped with front, rear and side armor plates known as
Enhanced Small Arms Protective Inserts. When worn together, the IOTV
will stop 7.62mm armor-piercing rounds.
Several vendors have demonstrated they can produce body armor that can
outperform the protection offered by IOTV with ESAPI.
[28]The Land Warrior system was sent in to battle in spring 2007 with
the 4th Battalion, 9th Infantry Regiment, 4th (Stryker) Brigade, 2nd
Infantry Division. At that time the deployed system weighed 10 pounds
(down from 17 pounds). The weight has been dropped to seven pounds,
and they expect to reduce it even further.
[29]Program Executive Office (PEO) Soldier was created by the Army
with one primary purpose: to develop the best equipment and field it
as quickly as possible so that our Soldiers remain second to none in
missions that span the full spectrum of military operations. PEO
soldier currently has 400 programs.
The Soldier Enhancement Program (SEP) is to identify and evaluate
commercially available individual weapons, munitions, optics, combat
clothing, individual equipment, water supply, shelters, communication
and navigational aids which can be adopted and provided to Soldiers in
three years or less.
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[46]Rate '$3 billion super soldier program: 10 times muscle endurance,
7 foot vertical leap, wall crawling, personal flight and more'
[47]Safe Human enhancement of strength, speed, endurance, cognition and
reducing aging effects and reducing obesity
[48]Selective androgen receptor modulators (SARM) increase the effect
of steroids on muscle and decrease effects where they could cause harm
such as in the prostate.
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[55]Body building sites have extensive information and tracking of the
development of SARMs as they are believed to be or enable safe/safer
steroids
The study concluded that ostarine increased lean mass and strength
without evidencing any androgenic side effects. Further ostarine
research into its use in treating the wasting related to cancer is
scheduled. The subjects in this study were all elderly, meaning they
likely all were experiencing the age related decline in anabolic
hormones (testosterone, DHEA, growth hormone, etc). Also, the degree
of gain in lean muscle mass was only 1.4kg after three months of
therapy for the highest dose group. The increase in speed (+15
percent) and power (+25 percent) measured during the stair climbing
was impressive though, suggesting the gain in lean mass was mostly
muscle. Effects were dose-dependent, meaning the higher the dose, the
greater the effects (within the range studied). If natural
testosterone concentrations are unaffected (this was not reported, so
that would be an assumption), then the ostarine would be supplementing
the anabolic effect of a person's natural testosterone levels, in
essence giving them the equivalent of a 125 200mg/week testosterone
ester head start.
[56]There are products available online that claim to be SARM.
This was covered on this site initially [57]when they were placed on
the anti-doping list
[58]Lan Bo Chen has developed a B-vitamin cocktail (mixed with green
tea) that increases mitochondrial output by enabling the mitochondria
to feed on fat instead of sugars. Studies on mice and high-performance
cyclists have shown this drink to be effective in increasing
performance by increasing endurance. [cyclists had a 3% performance
enhancement on 30 kilometer rides.] It can help a man in his 40's have
the mitochondrial activity of a twenty-year-old, it will do little for
a man in his 20's because his mitochondria are already working at full
capacity.
[59]Darpa has projects for Metabolic Dominance and Peak soldier
performance.
Darpa has renamed most of its biology programs, to make them sound
less like science fiction, and more like military necessities. For
example, "Persistence in Combat," the project to keep injured G.I.s
pulling the trigger on the battlefield for days, is now known as
"Soldier Self-Care." "Metabolic Dominance" is slated to become "Peak
Soldier Performance."
[60]Darpa has funded research into replicating the endurance of
Alaskan sled dogs in humans.
Before the race, the dogs' metabolic makeup is similar to humans.
Then suddenly they throw a switch -- we don't know what it is yet
-- that reverses all of that. In a 24-hour period, they go back to
the same type of metabolic baseline you see in resting subjects.
But it's while they are running 100 miles a day.
[61]The department of defense has a program for Optimized Human
Performance: Mitochondrial Energetics to enable older people to think
and have more of the fitness and energy of a younger person
The world contains approximately 4.2 billion people over the age of
twenty. Even a small enhancement of cognitive capacity in these
individuals would probably have an impact on the world economy
rivaling that of the internet. The commercial market for a compound
that could reverse the effects of aging on human energetics would
be more than significant. The cost of Social Security in the U.S.
is expected to approach 7% of the gross domestic product (GDP);
reducing this cost by any significant degree would also have
substantial impact on federal obligations and expenditures.
Ronald Evans at the Salk Institute is injecting the PPAR-delta gene to
reduce weight gain in mice and double exercise endurance.
Dr. Michael West, Biotime, believes that embryonic stem cells and
genetic engineering can safely radically extend human lives, enable
regenerative medicine, greatly enhance brain function and cognition
and enhance human performance. [Discover magazine "The Body" summer
2008 pg 82-86]
[62]A transcript of a show interviewing Julian Savulescu, ethicist
from Oxford University, that discussed genetic enhancement and in
particular IQ enhancement and society. Note: The show broadcast Aug
2007 discusses whole genome sequencing costing $50,000 within 5 years.
That price has already been reached in 2008.
Based on the lead abatement strategies the predictions are that if
you simply increased people's IQ, everyone's IQ by 3 points, which
is a very small increase, across a whole population, (so remember
the mean is 100), if you increased the whole population's IQ by
just 3 points, you would reduce poverty by 25%, you would reduce
welfare recipiency by 18%, the number of males in jail by 25%, the
number of parentless children by 20%. Now if I said to you, 'I have
a social program of love, care, counselling and social support that
would reduce the poverty rate by 25%', people would be jumping up
and down saying 'Why isn't this being instituted?' But here are
some data that suggests that increasing people's IQ by a very small
amount, could have those effects. Now as I said, even if that's out
by a factor of 10, the social effects are still significant.
People have estimated that an increase of 1 IQ point leads to a
nearly 2% increase in income, and for the US economy, an increase
per IQ point across the population, results in a $50-billion to
$60-billion increase in GDP, in national earnings. So the figures
can be quite striking. People have estimated, I can't remember the
figure exactly, but something like 15% of the US GDP is probably
accountable to the computing revolution and the added cognitive
power that computers have given human beings.
FURTHER READING
[63]Review of Darpa enhancement projects
[64]Therapeutic potential of the SARMs: revisiting the androgen
receptor for drug discovery
[65]Discussion of the ethics of cognitive enhancement
[66]Article on tumor receptor imaging as it relates to cancer
treatment
[67]Here is the 15 page study on cyclists (with enhanced speed from a
mitochondria boosting drink) which lists the FRS drink.
This project tested the effects of 6 weeks of twice daily FRS (Free
Radical Scavenger) dietary supplementation on 30 km cycling
time-trial (TT) performance. The FRS formula is a patent-pending
combination of flavonoids, vitamins, and other functional
ingredients that has energy-producing, performance-enhancing,
antioxidant, anti-inflammatory, and anti-cancer effects. The
primary active ingredient in FRS is quercetin, a flavonoid found in
onion skins, blueberries, and tea, which, when combined with the
other FRS ingredients, has been shown to produce measurable health
effects in animal and human studies.
Quercetin belongs to a group of plant pigments called flavonoids
that are largely responsible for the colors and protection of many
fruits, flowers, and vegetables. Scientists have identified more
than 4,000 flavonoids in nature, many of which provide a variety of
health benefits in humans, such as protection against cancer and
cell damage caused by oxidation. The other ingredients in FRS work
in a synergistic way with quercetin. Many of these ingredients,
such as caffeine and B-vitamins, help to increase the concentration
of quercetin in blood plasma thereby increasing its overall
effectiveness and benefits.
[68]This company is claiming to sell the drink based on the research
which corresponds to the name of the drink in the study.
[69]Here is Lan bo Chen's webpage with a listing of his publications
[70]Follow up work on the Lan Bo chen drink and other enhancement is
ongoing at Natick Soldier systems
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----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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