[tt] Next Big Future - 7 new articles
Eugen Leitl
<eugen at leitl.org> on
Fri Jul 11 08:36:07 UTC 2008
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Date: Fri, 11 Jul 2008 03:21:56 -0400
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Subject: Next Big Future - 7 new articles
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"[2]Next Big Future" - 7 new articles
1. [3]YCBO superconductor at 105K and upcoming 195K superconductor
2. [4]Myostatin inhibitors funded for muscle regeneration of war
injuries
3. [5]DNA sewing machine
4. [6]Now that is a long comment thread
5. [7]Carnival of Space Week 62
6. [8]Terabit per second internet coming soon
7. [9]High magnetism reveals the inner electronic structure of high
temperature superconductors
8. [10]More Recent Articles
9. [11]Search Next Big Future
[12]YCBO superconductor at 105K and upcoming 195K superconductor
[13]Superconductors.org reports the critical transition temperature
(Tc) of the industrial superconductor YBCO (YBa2Cu3O7) has been
successfuly increased from 92K to near 105K by reformulating to
Y3Ba5Cu8Ox. No new elements were added.
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Y-358 - dubbed "Ultra YBCO" - is a novel intergrowth incorporating two
different types of planar weight disparity (PWD) and a larger unit
cell (around 31.2Ã). The target structure, shown below left, is
colinear and does not incorporate branching of the CuO2 chains, as
occurs in the Y-124 and Y-247 structure types.
Other YBCO variants have also been discovered by Superconductors.ORG,
but had limitations vis-a-vis standard YBCO. "Super YBCO" (Tc up to
107K) required the use of an expensive heavy rare earth oxide to
synthesize. And "Enhanced YBCO" (Tc 97K) was not homogenous. Its
volume fraction appeared to be around 30%. Ultra YBCO should cost no
more than standard YBCO to manufacture.
Synthesis of the material was by the solid state reaction method.
Stoichiometric amounts of the below precursors were mixed, pelletized
at 70,000 psi and sintered for 11 hours at 890C. The pellet was then
annealed for 10 hours at 500C in flowing O2.
Superconductors.org [20]is also teasing that they have a
superconductor that works at 195K which is the[21] dry ice sublimation
temperature [-78 Celsius which is 195 Kelvin]
So this year has seen excellent experimental progress being made to
room temperature (300K) superconductors as well as [22]theoretical
progress. There has also been the [23]whole new class of higher
temperature iron based superconductors.
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[41]Myostatin inhibitors funded for muscle regeneration of war injuries
[42]A $1.2 million grant from the Office of Naval Research to Dr.
Hamrick,bone biologist in the Medical College of Georgia Schools of
Graduate Studies and Medicine, is enabling laboratory studies of two
experimental myostatin inhibitors: a decoy receptor and a binding
protein, both developed by MetaMorphix, Inc. of Beltsville, Md. Both
inhibitors have been shown effective in muscle regeneration, but this
is the first trial that looks at their impact on bone.
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They are studying two myostatin inhibitors in mice with limb
injuries, first to see which works best and then to identify the
best delivery mechanism, says Dr. Mark Hamrick, bone biologist in
the Medical College of Georgia Schools of Graduate Studies and
Medicine.
"Fifty to 60 percent of the injuries occurring in Iraq are to the
limbs, and the average injury requires five surgeries," Dr. Hamrick
says. "Myostatin inhibitors are known to improve muscle
regeneration and we have evidence that they also increase bone
formation. We believe these inhibitors will result in a stronger,
more rapid recovery for these soldiers and other victims of
traumatic limb injuries."
Bone and muscle healing typically go hand in hand. Muscle provides
blood, growth factors and potentially stem cells for a healing
callus. It's not yet known how well bones reciprocate. "If you can
improve muscle healing, you can improve bone healing," Dr. Hamrick
says. "Young people have a tremendous potential to heal that can be
improved with better approaches to preventing infection and to
healing soft tissue and bone in an integrated manner."
Researchers hope to move to clinical trials in two to three years,
Dr. Hamrick says. "If we find the primary role of myostatin is very
early in the healing process and see a big jump in expression early
in a fracture callus, it may be that a single injection bolus
immediately after injury is the best time for treatment rather than
continued treatment over a period of time."
FURTHER READING
Roughly the same article, but the Medical College site has some link
issues.
[49]Augusta Chronicle coverage
[50]Science Daily coverage
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[68]DNA sewing machine
[69]DNA sewing machine created by Kyohei Terao from Kyoto University
and colleagues. They designed laser-directed microdevices to pick up
and manoeuvre giant individual molecules of DNA. The technology will
also be useful for a number of other applications including DNA
sequencing and molecular electronic. This should help enable the goals
of $10-1000 whole genome sequencing and help with DNA manufacturing
(using DNA as a structural material). There is a lot of further
potential for more specially designed microtools and structures for
improving the manipulation of DNA and other molecules.
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[76]The full article is here
In conclusion, we have demonstrated the method and device for
on-site single-molecule manipulation of giant DNA molecules, using
optically driven microstructures for picking up and separating a
DNA fibers from a bundle. We used a microfabricated hook together
with winding/unwinding of the DNA fiber onto microfabricated
bobbins. This method enables the manipulation of DNA molecules in
the order of mega base pairs under a microscope without
fragmentation. The method is purely mechanical, and requires no
chemical modifications; moreover, it can manipulate any desired
part of the targeted DNA in the microscope view. This method will
create avenues for space-resolved single molecule assays of large
chromosomal DNA, along with its applications in gene location and
epigenetic studies.
Single molecule analysis of DNA is limited by the difficulty of
stretching out and handling these long molecules - eukaryotic DNA
can range from millimetres to centimetres. A giant DNA molecule is
very fragile, explains Terao, so to catch it and manipulate it
without breaking it is a challenge.
Thinking of a strand of DNA as a piece of sewing thread, Terao
developed microhooks to pick up the DNA, just like we would use our
fingers to pick up thread. When thread is very long it becomes
tiresome to manipulate it just with our fingers and instead we wind
it around bobbins to make it compact. This is what inspired us to
use microbobbins, says Terao.
Optical tweezers - where tightly focused laser beams trap and hold
tiny objects - are used to catch and move these microdevices. The
z-shaped microhook is directed by the tweezers to pick up a single
strand of DNA, and barbs in the openings of the hook prevent the
caught DNA unhooking. In the case of bobbins, two focused laser
beams are used to revolve one bobbin around the other. The
revolving motion winds the DNA molecule between the two bobbins.
This DNA manipulation technique should prove useful in applications
such as fluorescence in situ hybridisation (FISH), says Terao.
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[94]Now that is a long comment thread
[95]The big news out of Iraq is that Lara Logan, the chief foreign
affairs correspondent for CBS News, tells The Washington Post she is
pregnant, and the father is a married federal contractor whom she met
while stationed in Iraq. H/T [96]instapundit
The one thing that I would note is that the comment thread is already
over 2700 comments and one would have to page through them ten at
time.
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[114]Carnival of Space Week 62
[115]Dave Mosher at discovery.com has an excellent Carnival of Space
week 62 The slideshow presentation and article layout are top notch
and the content of twenty articles is excellent as well. Space Disco
is one of the seven new blogs you'll find at Discovery Space. Bad
Astronomy is one of the blogs thathas moved to discovery.com.
[116]This site contributed the latest discussion of a 100MW version as
the next step for the IEC fusion reactor project
[117]Centauri dreams has an article by Marc Millis laying out the
current status of the Tau Zero Foundation, a non-profit looking at
ways to achieve breakthroughs for interstellar travel.
[118]A Babe In The Universe looks reviews the space angles of the
International Conference of Environmental Systems in San Francisco.
Check out the [119]Space Disco for a lot more in the Carnival of Space
week 62
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[137]Terabit per second internet coming soon
[138]Researchers at the University of Sydney have developed technology
that could boost the throughput of existing networks by sixty to
100-fold without costing the consumer any more, and its all thanks to
a scratch on a piece of glass.
After four years of development, University of Sydney scientists
say the Internet is set to become on average 60 times faster than
existing networks.
"The scratched glass we've developed is actually a photonic
integrated circuit," Eggleton said.
"This circuit uses the 'scratch' as a guide or a switching path for
information - like when trains are switched from one track to
another - except this switch takes only one picosecond to change
tracks. This means that in one second the switch is turning on and
off about one million times. We are talking about photonic
technology that has terabit per second capacity."
An initial demonstration proved it possible to achieve speeds 60
times faster than existing local networks.
[139]Applications of Highly-Nonlinear Chalcogenide Glass Devices
Tailored for High-Speed All-Optical Signal Processing
Ultrahigh nonlinear tapered fiber and planar rib Chalcogenide
waveguides have been developed to enable high-speed all-optical
signal processing in compact, low-loss optical devices through the
use of four-wave mixing (FWM) and cross-phase modulation (XPM) via
the ultra fast Kerr effect. Tapering a commercial
$hbox{As}_{2}hbox{Se}_{3}$ fiber is shown to reduce its effective
core area and enhance the Kerr nonlinearity thereby enabling XPM
wavelength conversion of a 40 Gb/s signal in a shorter 16-cm length
device that allows a broader wavelength tuning range due to its
smaller net chromatic dispersion. Progress toward photonic
chip-scale devices is shown by fabricating
$hbox{As}_{2}hbox{S}_{3}$ planar rib waveguides exhibiting
nonlinearity up to $2080, {rm W}^{-1}cdot hbox{km}^{-1}$ and losses
as low as 0.05 dB/cm. The material's high refractive index,
ensuring more robust confinement of the optical mode, permits a
more compact serpentine-shaped rib waveguide of 22.5 cm length on a
7-cm-size chip, which is successfully applied to broadband
wavelength conversion of 40-80 Gb/s signals by XPM. A shorter 5-cm
length planar waveguide proves most effective for all-optical
time-division demultiplexing of a 160 Gb/s signal by FWM and
analysis shows its length is near optimum for maximizing FWM in
consideration of its dispersion and loss.
Speeding up the Internet 100 times is just a stepping stone to a
Photonic Chip
The [140]Centre for Ultrahigh bandwidth Devices for Optical Systems
(CUDOS) vision is the Photonic Chip.
FURTHER READING
[141]Centre for Ultrahigh bandwidth Devices for Optical Systems
(CUDOS) Research
[142]All-optical and nonlinear signal processing
[143]Microstructured and tapered fibre devices
[144]Optical waveguide gratings and slow light
[145]Photonic crystals
[146]Optofluidics
So why use microfluidics in conjunction with microphotonics? The
combination of these fields potentially allows one to impart
adjustable photonic control in new ways that are highly compact and
tuneable. We may also turn the technology around and use photonics
to sense fluid properties, which is of increasing importance to
medical diagnostics.
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[164]High magnetism reveals the inner electronic structure of high
temperature superconductors
[165]University of Cambridge researchers have discovered where the
charge 'hole' carriers that play a significant role in the
superconductivity originate within the electronic structure of
copper-oxide superconductors. A correct and detailed understanding
what is going on in high temperature superconductors will help to get
to a correct theory for superconductors and can lead to the
development of room temperature superconductors. This work has
revealed how magnetism and superconductance interact. This is part of
a series of major discoveries in the field of superconductors this
year.
These findings are particularly important for the next step of
deciphering the glue that binds the holes together and determining
what enables them to superconduct.
Dr Suchitra E. Sebastian, lead author of the study, commented, "An
experimental difficulty in the past has been accessing the
underlying microscopics of the system once it begins to
superconduct. Superconductivity throws a manner of 'veil' over the
system, hiding its inner workings from experimental probes. A major
advance has been our use of high magnetic fields, which punch holes
through the superconducting shroud, known as vortices - regions
where superconductivity is destroyed, through which the underlying
electronic structure can be probed.
"We have successfully unearthed for the first time in a high
temperature superconductor the location in the electronic structure
where 'pockets' of doped hole carriers aggregate. Our experiments
have thus made an important advance toward understanding how
superconducting pairs form out of these hole pockets."
The paper 'A multi-component Fermi surface in the vortex state of an
underdoped high-Tc superconductor' will be published in the 09 July
edition of Nature.
By determining exactly where the doped holes aggregate in the
electronic structure of these superconductors, the researchers have
been able to advance understanding in two vital areas:
(1) A direct probe revealing the location and size of pockets of
holes is an essential step to determining how these particles stick
together to superconduct.
(2) Their experiments have successfully accessed the region betwixt
magnetism and superconductivity: when the superconducting veil is
partially lifted, their experiments suggest the existence of
underlying magnetism which shapes the hole pockets. Interplay
between magnetism and superconductivity is therefore indicated -
leading to the next question to be addressed.
Do these forms of order compete, with magnetism appearing in the
vortex regions where superconductivity is killed, as they suggest?
Or do they complement each other by some more intricate mechanism?
One possibility they suggest for the coexistence of two very
different physical phenomena is that the non-superconducting vortex
cores may behave in concert, exhibiting collective magnetism while
the rest of the material superconducts.
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More Recent Articles
* [183]Myostatin blocking still under hot pursuit
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----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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