[tt] Next Big Future - 3 new articles
Eugen Leitl
<eugen at leitl.org> on
Thu Jul 3 08:30:54 UTC 2008
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Date: Thu, 03 Jul 2008 02:31:51 -0400
To: eugen <eugen at leitl.org>
Subject: Next Big Future - 3 new articles
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"[2]Next Big Future" - 3 new articles
1. [3]Dr Daniel Haber's cancer circulating tumor cell blood test CTC
chip used to track cancer progress in realtime
2. [4]Intel's Gelsinger sees clear path to 10 nanometer lithography
3. [5]Hypersonic Falcon HTV-3X
4. [6]More Recent Articles
5. [7]Search Next Big Future
[8]Dr Daniel Haber's cancer circulating tumor cell blood test CTC chip used
to track cancer progress in realtime
[9]The blood test requires a 10 milliliter blood sample -- just two
teaspoons. It takes about eight hours to send the blood across the
80,000 tiny columns so a specially designed antibody glue can latch
onto passing cancer cells. It was used to detect cancer in 27 people
and helped to track the progress of cancer in near real time. This
will help determine what treatments are working and a genetic
fingerprint of the current state of any tumor. This should lead to
better cancer treatment and earlier detection and better disease
monitoring
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Haber and his colleagues analyzed blood samples from 27 patients
with non-small cell lung cancer, 23 who had EGFR gene mutations and
four who did not. CTCs were identified in all samples and in
genetic analyses from mutations 92 percent of the time.
Mutations in EGFR, a protein, can help predict whether these tumors
will respond to a family of drugs called tyrosine kinase
inhibitors.
"Even in the three to four months that we followed patients, the
genetic make-up of the tumors changed. Resistant mutations appear
and other mutations appear, obviously because we're doing things
[with drug therapy] to the cancer," Haber said. "But the way we
practice oncology we don't typically test for that. We do one
biopsy which takes a tiny, tiny amount and assume that for the rest
of the course, the tumor is the same."
"It's important to know in real time what you're treating," he
continued. "We need to be able to follow the patient without
needing to re-biopsy the tumor every time."
A previous study published in Nature used the CTC (Circulating
Tumor Cells) chip technology to look at CTCs in lung, pancreatic,
prostate, breast and colon cancers. The CTC chip successfully found
such cells in 99 percent of the samples.
Schiller, of the University of Texas Southwestern Medical Center in
Dallas, said there are practical questions about whether enough
cells can be extracted to make the technique effective and whether
it will work for other types of tumors.
Haber said he believes it will.
The CTC chip, licensed to the privately held CellPoint Diagnostics
in Mountain View, California, is 100 times more sensitive than a
U.S. Food and Drug Administration-approved technique that uses
magnetic beads to try to extract cancer cells, according to Haber.
"I think this is key to personalized medicine," said Dr. Daniel
Haber, senior author of a paper detailing the technology, to be
published in the July 24 issue of the New England Journal of
Medicine but released early online Wednesday. "As we get to
targeted therapies in increasing numbers, and increasing
understanding about the genetics that guide targeted therapies, we
need a way to know what we're treating."
[16]The technology is in its infancy, however. "This is still in a
very, very early stage where it takes a long time to handle every
sample, to flow the blood through the chip," Haber said. "This is a
proof of principle that we can do this. We need a much more
automated system for larger clinical trials."
Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in
New York City, said that "you have to have some circulating cells
to do this test, but it's very exciting because they're getting a
genetic fingerprint of a tumor which will tell an oncologist what
therapy the tumor might respond to or not respond to.
"It's expensive, but it may well be that if we can identify
patients who can have a personalized regimen that works, we will be
saving the cost of treating all those patients with regimens that
don't work," he added.
FURTHER
[17]Megpagetoday coverage
[18]Web MD coverage of the CTC chip
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[35]Rate 'Dr Daniel Haber's cancer circulating tumor cell blood test
CTC chip used to track cancer progress in realtime'
[36]Intel's Gelsinger sees clear path to 10 nanometer lithography
[37]Intel's Pat Gelsinger (NSDQ:INTC) sees a "clear way" to
manufacturing chips under 10 nanometers and when the semiconductor
industry transitions to 450mm silicon wafers around 2012, the number
of companies that run their own fabs will drop into the single digits.
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Intel debuted its 45nm process late last year and has been ramping its
Penryn line of 45nm processors steadily throughout this year. The next
die shrink milestone will be the 32nm process, set to kick off next
year, followed by 14nm a few years after that and then sub-10nm, if
all goes according to plan.
Gelsinger described the elemental hoops Intel has had to jump through
to achieve each "tick" milestone in the chip maker's relentless
pursuit of Moore's Law, noting that while each new process adds
materials used in novel ways, modern processors are still built on a
"silicon scaffolding."
"We are putting more and more of the periodic table onto that silicon
scaffolding. Today we use about half of the elements on the periodic
table. When [Intel co-founder Robert] Noyce and Moore started, they
used six elements," Gelsinger said.
"We replaced the gate with high-K, we put metal on top of it, but it's
still, quote, silicon. [The process of getting smaller] keeps moving
forward. It may be carbon nanotubes next or it may be spintronics. But
we'll keep moving forward."
ULTIMATE LIMITS
[44]Previously Intel has forecast moore's law to continue to at least
2029.
[45]This site has covered the future of lithography
[46]There is going to be substantial re-architecting with more
photonics and other changes like the Tensilica processors.
The GPGPU, FPGA, custom tensilica processors and cell type processors
seem like the way forward. Plus the new universal memories.
[47]New molecular computing architectures could have an impact or a
niche.
A successful and inexpensive 3D architecture needs to be perfected.
Ultimate limits will not be seen until we have 3D, 10 nanometer or
less optical systems and are pushing the limits of cooling the heat
generated and energy to power the devices. The technologies that could
be involved are plasmonics, excitons, spintronics, metamaterials, room
temperature superconductors and better cooling systems. There will be
re-architecting with reversible computing architecture and more
efficient parallel computing architectures.
So a 10 centimeter cube would have 10 million multi-nanometer layers.
One layer of computing would be about 10 million times more powerful
than what we currently have. so the small fist size cube would be100
trillion to 1000 trillion times more powerful for personal computing.
This means 100,000 to 1 million zettaflops (10*23 to 10**24). Plus
each person could have a few cubic meters of computronium. For
several more thousand times more compute power.
Heading to 1-2 nanometer feature and component sizes would probably
also be possible for another 1000 times boost (The previous insane
amount of compute power ought to help find a way to squeeze out
another 1000-1 million improvement) (10**27 to 10**30)
For [48]non-heroic cooling limits: 10**24 to 10**26 bits per cm**2
(but we added the third dimension for 10 million to 100 million fold
gains)
There will also be [49]comparable levels of scale and density for
quantum computers (10**23 to 10**32 qubits)
All the individual compute power will be networked together across the
solar system. The connection speeds will also be pushing whatever
physical limits there are.
FURTHER READING
[50]Intel is researching applications for this compute power
[51]30 page transcript from the IDF (Intel Developers Forum) spring
2008 keynote address by Pat Gelsinger
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[69]Hypersonic Falcon HTV-3X
Falcon HTV-3X
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[76]The Blackswift Hypersonic program may not get fully funded for the
$750 million that it needs, but the program has
a lot of interesting technology and innovations for greater
efficiency. This technology and innovations are discussed below.
[77]Making a scramjet rocket would be a better program to fund for
space access. A scramjet rocket would be simpler and cheaper than a
space plane and would not need to have the weight of wings and other
gear.
[78]From the designers of Skylon, there is a fairly practical
spaceplane design. It is called the Mach 5 A2 commercial Concorde
replacement.
[79]The MHD bypass to slow the supersonic air so that a turbine can
function while the scramjet goes up to Mach 7
However, there is a lot of interesting technology in the Blackswift
program. Constant volume combustion, more efficient than Brayton cycle
Humphrey cycle propulsion (like a pulse-detonation engine).
The goal is to achieve a flying Mach 6 demonstrator by 2013.
It would use regular fuel instead of hydrogen, which would be more
practical but have relatively lower performance.
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----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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