[tt] Next Big Future - 4 new articles
Eugen Leitl
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Wed Jul 2 06:41:49 UTC 2008
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Date: Wed, 02 Jul 2008 02:18:18 -0400
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Subject: Next Big Future - 4 new articles
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"[2]Next Big Future" - 4 new articles
1. [3]Breakthrough diagnosis for drug resistant Tuberculosis which
kills 1.5 million per year
2. [4]World's First Commercial High Temperature Nuclear Reactor
starts construction in China in 2009
3. [5]Zinc Finger Proteins Put Personalized HIV Therapy Within Reach
4. [6]Participated in a podcast on the Speculist about the Future of
Fit and Fat
5. [7]More Recent Articles
6. [8]Search Next Big Future
[9]Breakthrough diagnosis for drug resistant Tuberculosis which kills 1.5
million per year
[10]"We are capable now of making a diagnosis of MDR-TB within hours,"
Mario Raviglione, director of the WHO's Stop TB department said. He
used the acronym for multi-drug resistant tuberculosis, an infection
that cannot be cured with a standard course of antibiotics. The
[11]The DNA tests cost an avearge of $5 per test, and training is
rather simple.
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This is part of a wave of arriving or soon to arrive cheap and
effective diagnostics and biomarker tests which [18]help reduce the
death rate from cancer and [19]other diseases. [20]There have been
several advancements on better diagnosis tools including [21]$10 USB
stick testing labs on a chip.
[22]TB affects the lungs and can be transmitted by an infected person
in droplets through coughing, sneezing, singing and other activities.
The disease infected 9.2 million people in 2006, turning it into the
world's second-most-fatal infectious disease after AIDS. So in recent
days we have the announcement of major breakthroughs against the
[23]number 1 infectious disease AIDS (Zinc fingers for personal immune
system boost to keep control of the Hiv virus levels) and now this
test for the number 2 infectious disease MDR-TB.
The molecular test developed by Hain Lifescience and Innogenetics
(INNX.BR) represented a big breakthrough in the fight against
tuberculosis, a contagious respiratory ailment that kills 1.5
million people a year.
The new test can determine directly from a patient's saliva whether
the tuberculosis bacteria can be treated with the two main
antibiotics, isoniazid and rifampicin, making it easier to
prescribe the drug to cure the disease and prevent its spread.
Drug-resistant tuberculosis strains are particularly lethal for
HIV/AIDS sufferers and those with weak immune systems. Errors in
prescribing antibiotics can worsen drug resistance problems and lead
to XDR-TB, an untreatable form that has emerged in 49 countries
including the United States, France, Russia, South Africa, Brazil and
Australia.
The Germany-based Hain Lifescience is also working on a test to
diagnose XDR, which remains in an experimental stage, a WHO spokesman
said.
Lesotho will be the first country to get the lab equipment and
training to use the new diagnostics under a programme supported by the
WHO's partners UNITAID and the Foundation for Innovative New
Diagnostics, Raviglione told a news briefing.
The other countries due to receive support to use the new test in the
next four years are: Azerbaijan, Bangladesh, Cote d'Ivoire, the
Democratic Republic of Congo, Ethiopia, Georgia, Indonesia,
Kazakhstan, Kyrgyzstan, Lesotho, Moldova, Myanmar, Tajikistan,
Ukraine, Uzbekistan, and Vietnam.
The WHO said this deployment, as well as efforts to make second-line
antibiotics more affordable, should increase to 15 percent the
proportion of patients with multi-drug resistant tuberculosis who are
diagnosed and treated appropriately. At present, that rate is only 2
percent. So the 13% increase would mean about 195,000 lives saved each
year. A global tuberculosis case finding and treatment program would
cost in the range of $1 billion and is the 13th item on a [24]cost
benefit analysis by the Copenhagen consensus.
An expert panel of 8 economists, including 5 Nobel Laureates, ranked a
list of the most promising solutions to [25]ten of the most pressing
challenges facing the world today in May 2008 in Copenhagen.
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[42]Rate 'Breakthrough diagnosis for drug resistant Tuberculosis which
kills 1.5 million per year'
[43]World's First Commercial High Temperature Nuclear Reactor starts
construction in China in 2009
[44]Schematic of the HTR-PM (High temperature reactor pebble bed
module) Link is to eight page design paper.
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[51]A 200 MWe high temperature reactor will be the safest nuclear
power plant ever designed and built. High temperature reactors can be
adapted to use thorium for fuel and the plan is for factory mass
produced reactors. Two year construction times and mass production
driving costs down to less than half the cost of the first units.
China sees these as supplemental reactors to the big reactors. They
will be used in smaller cities and towns and by factories for
generating industrial heat. Also, they are looking to use heat for
hydrogen generation, desalination and coal liquification (at least
that would be cleaner than straight coal burning).
The major safety issue regarding nuclear reactors lies in how to cool
them efficiently, as they continue to produce residual heat even after
shutdown. Gas-cooled reactors discharge surplus heat and don't need
additional safety systems like water-cooled reactors do. The HTR-10
was subject to a test of its intrinsic safety in September 2004 when,
as an experiment, it was shut down with no cooling. Fuel temperature
reached less than 1600 C and there was no failure.
"Using the existing operating HTR-10 reactor at the Institute of
Nuclear and New Energy Technology of Tsinghua University in Beijing,
we have already done what would be unthinkable in a conventional
reactor--we switched off the helium coolant and successfully let the
reactor cool down by itself," said Wu.
A Simpler, More Rational Way to Think about Nuclear Safety: [52]FOUR
LEVELS OF SAFETY*
[Definition developed by Professor Lawrence Lidsky, Massachusetts
Institute of Technology.]
LEVEL 0:
No hazardous materials or confined energy sources.
LEVEL 1:
No need for active systems in event of subsystem failure. Immune to
major structural failure and operator error.
LEVEL 2:
No need for active systems in event of subsystem failure. No immunity
to major structural failure or operator error.
LEVEL 3:
Positive response required to subsystem malfunction or operator error.
Defense in depth. No immunity to major structural failure.
The MHR is the only reactor that meets the criterion of Level 1
safety.
Second, the modular design enables the plant to be assembled much
quicker and cost-effectively than traditional nuclear generators. Its
streamlined construction timetable is also a first for the nuclear
power industry, where designing and building generators usually take
decades, rather than years.
The modules are manufactured from standardized components that can be
mass-produced, shipped by road or rail and assembled relatively
quickly. The new plants are smaller and new modules can be added as
needed. Multiple reactors can be linked around one or more turbines,
all monitored from a single control room. The site of the Shidaowan
project will install 18 additional modules, which will total 3,800
MWe.
[53]A demonstration high-temperature gas-cooled reactor, the HTR-PM of
200 MWe was approved in November 2005, to be built at Shidaowan, near
Rongcheng in Weihai city, Shandong province by Huaneng Shidaowan
Nuclear Power Company. This consortium is led by the China Huaneng
Group Co. - the country's largest generating utility but hitherto
without nuclear capacity. The project received environmental clearance
in March 2008 for construction start in 2009 and commissioning by
2013.
The Modular High Temperature Pebble Bed reactor should also use half
of the steel and one third of the concrete of Light Water reactors.
A 10 MWt high-temperature gas-cooled demonstration reactor (HTR-10),
having fuel particles compacted with graphite moderator into 60mm
diameter spherical balls (pebble bed) was commissioned in 2000 by the
Institute of Nuclear Energy Technology (INET) at Tsinghua University
near Beijing. It reached full power in 2003 and has an outlet
temperature of 700-950°C and may be used as a source of process heat
for heavy oil recovery or coal gasification. It is similar to the
South African PBMR intended for electricity generation. It was subject
to a test of its intrinsic safety in September 2004 when as an
experiment it was shut down with no cooling. Fuel temperature reached
less than 1600°C and there was no failure.
Initially the HTR-10 has been coupled to a steam turbine power
generation unit, but second phase plans are for it to operate at 950°C
and drive a gas turbine, as well as enabling R&D in heat application
technologies. This phase will involve an international partnership
with Korea Atomic Energy Research Institute (KAERI), focused
particularly on hydrogen production.
A key R&D project is the demonstration Shidaowan HTR-PM of 200 MWe
(two reactor modules, each of 250 MWt) which is being built at
Shidaowan in Shandong province, driving a single steam turbine at
about 40% thermal efficiency.
The 40% efficiency of a MHR driving steam can turbine can be seen.
China will switch to higher efficiency [54]gas turbine cycle in later
versions.
The size was reduced to 250 MWt from earlier 458 MWt modules in order
to retain the same core configuration as the prototype HTR-10 and
avoid moving to an annular design like South Africa's PBMR.
China Huaneng Group, one of China's major generators, is the lead
organization in the consortium with China Nuclear Engineering &
Construction Group (CNEC) and Tsinghua University's INET, which is the
R&D leader. Chinergy (a 50-50 joint venture of INET and CNEC) is the
main contractor for the nuclear island. Projected cost is US$ 430
million, with the aim for later units being US$ 1500/kWe. The
licensing process is under way with NNSA and construction is likely to
start early in 2009 with completion expected in 2013.
The HTR-PM will pave the way for 18 (3x6) further 200 MWe units at the
same site in Weihai city - total 3800 MWe - also with steam cycle.
INET is in charge of R&D, and is aiming to increase the size of the
250 MWt module and also utilise thorium in the fuel. Eventually a
series of HTRs, possibly with [55]Brayton cycle directly driving the
gas turbines, will be factory-built and widely installed throughout
China.
In March 2005 an agreement between PBMR of South Africa and Chinergy
of Beijing was announced. PBMR Pty Ltd is has been taking forward the
HTR concept (based on earlier German work) since 1993 and is ready to
build a 125 MWe demonstration plant. Chinergy Co. is drawing on the
small operating HTR-10 research reactor at Tsinghua University which
is the basis of their 100 MWe HTR-PM demonstration module which also
derives from the earlier German development.
Both PBMR and HTR-PM are planned for operation about 2013. The new
agreement is for cooperation on the demonstration projects and
subsequent commercialisation, since both parties believe that the
inherently safe pebble bed technology built in relatively small units
will eventually displace the more complex light water reactors.
[56]General Atomics of the United States with Russian partners have
had an advanced modular helium reactor design completed since 2001,
but actual construction has been stalled
China will be heading towards the GT-MHR design in stages of actually
completed reactors.
[57]The gas turbine part of the reactor design
The chinese steam cycle MHR will achieve much of the benefits of the
Gas Turbine MHR and the gas turbine version chinese reactors will have
roughly the same benefits in terms of less nuclear waste.
FURTHER READING
[58]High temperature reactor history
[59]Iris reactor license application inactive until 2010.
[60]Documentation on the Iris reactor
[61]High Temperature reactor conference
[62]France also has a high temperature reactor design the Anteres, but
they do not have firm construction plans
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starts construction in China in 2009'
[80]Zinc Finger Proteins Put Personalized HIV Therapy Within Reach
[81]- Researchers at the University of Pennsylvania School of Medicine
and collaborators are using minute, naturally occurring proteins
called zinc fingers to engineer T cells to one day treat AIDS in
humans.
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The first steps have been taken towards the goal of using modified
T cells from an HIV-infected person for their own treatment. They
showed that, using the zinc fingers, they could reduce the viral
load of immune-deficient mice transplanted with engineered T cells.
Normally, zinc fingers bind to different bases in the DNA sequence
to regulate the activity of genes. The zinc fingers used in this
experiment were designed to bind to specific DNA sequences in the
CCR5 gene. The CCR5 protein is one of the two cell-surface
receptors needed for HIV to gain entry into a T cell in order to
replicate.
In this study, the zinc finger protein brings a DNA enzyme to the
CCR5 gene to cut a portion of its sequence, but due to the repair
process a new mutation arises in the CCR5 protein, rendering it
non-functional. Without a functional CCR5 protein on the cell's
surface, HIV cannot enter, presumably leading to resistance to HIV
infection.
The researchers demonstrated this process in cell culture and in a
mouse model. For the animal part of the study, the investigators
used healthy human CD4 T cells and added DNA that expresses the
zinc fingers, which modifies the CCR5 co-receptor. They grew the
engineered cells in tissue culture flasks and transferred them into
immune-deficient mice infected with HIV. "We followed them over
time and showed that those mice that received the
zinc-finger-treated cells showed less viral load than controls and
improved CD4 counts," says Perez.
The researchers are planning a clinical trial in humans in which T
cells from HIV patients would have their CCR5 gene deliberately
knocked out. These modified T cells could then be infused back into
the patients to re-establish their immune system and decrease their
viral load.
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[104]Rate 'Zinc Finger Proteins Put Personalized HIV Therapy Within
Reach'
[105]Participated in a podcast on the Speculist about the Future of Fit and
Fat
[106]Sunday night Phil Bowermaster and Stephen Gordon hosted a panel
on The Future of of Fit (and Fat). The panelists were PJ Manney, Brian
Wang, and fitness expert and entrepreneur Shawn Phillips.
Shawn Phillips is an author, entrepreneur, and expert in the area
of performance training and nutrition. He created the Full
Strength® Premium Nutrition Shake, clinically proven to swap body
fat for lean muscle. He is the author of ABSolution: The Practical
Guide to Building Your Best Abs and has just released Strength for
Life, published by Ballantine/Random House.
PJ Manney is a writer and futurist and a leading voice in the H+
movement. She has written extensively on transhumanism and related
topics, as well as for television (Xena Warrior Princess and
Hercules the Legendary Journeys) , and has a novel under
development. PJ is the Chairman of the board of directors of the
World Transhumanist Association, she's a senior associate at the
Foresight Nanotech Institute, and she is on the scientific advisory
board for the Lifeboat Foundation.
Brian L. Wang, M.B.A. is the Director of Research for the Lifeboat
Foundation. Brian is a long time futurist who has been involved
with nanotechnology associations since 1994. He is now a member of
the Center for Responsible Nanotechnology (CRN) Task Force where he
moderates the technology sub-task force. He is also on the
Nanoethics Group Advisory Board. He is also the mastermind behind
Next Big Future.
Check out the notes on the podcast and the podcast itself over at the
Speculist.
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More Recent Articles
* [124]Molecular Genetics of Aging conference september 24-28, 2008
* [125]Electrostatic-based DNA Microarray Technique Could
Revolutionize Medical Diagnostics
* [126]LIFT cancer clinical trials
* [127]UCLA Sens anti-aging conference abstracts
* [128]Iraqis: 43% say Iraq is going well while 17% of americans say
USA on right track
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----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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