[tt] Next Big Future - 3 new articles
Eugen Leitl
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Tue Apr 1 08:11:06 UTC 2008
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Date: Tue, 01 Apr 2008 03:24:40 -0400
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Subject: Next Big Future - 3 new articles
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"[2]Next Big Future" - 3 new articles
1. [3]Stanford researchers develop tool that 'sees' internal body
details 1,000 smaller
2. [4]Fermi paradox, metamaterials, dark matter, recent science and
advanced aliens fading into the background
3. [5]Gene Therapy Breakthrough- Three Micro RNA inhibition
injections reduces cholesterol 30%, 2013 for human use
4. [6]More Recent Articles
5. [7]Search Next Big Future
[8]Stanford researchers develop tool that 'sees' internal body details 1,000
smaller
[9]Stanford University School of Medicine researchers has developed a
new type of imaging system that can illuminate tumors in living
subjects--getting pictures with a precision of nearly on nanometer
(one-trillionth of a meter).
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This technique, called Raman spectroscopy, expands the available
toolbox for the field of molecular imaging, said team leader Sanjiv
Sam Gambhir, MD, PhD, professor of radiology. signals from Raman
spectroscopy are stronger and longer-lived than other available
methods, and the type of particles used in this method can transmit
information about multiple types of molecular targets
simultaneously.
"Usually we can measure one or two things at a time," he said.
"With this, we can now likely see 10, 20, 30 things at once."
Gambhir said he believes this is the first time Raman spectroscopy
has been used to image deep within the body, using tiny
nanoparticles injected into the body to serve as beacons.
When laser light is beamed from a source outside the body, these
specialized particles emit signals that can be measured and
converted into a visible indicator of their location in the body.
Imaging of animals and humans can be done using a few different
methods, including PET, magnetic resonance imaging, computed
tomography, optical bioluminescence and fluorescence and
ultrasound. However, said Gambhir, none of these methods so far can
fulfill all the desired qualities of an imaging tool, which include
being able to finely detect small biochemical details, being able
to detect more than one target at a time and being cheap and easy
to use.
Postdoctoral scholars Shay Keren, PhD, and Cristina Zavaleta, PhD,
co-first authors of the study, found a way to make Raman
spectroscopy a medical tool. To get there, they used two types of
engineered Raman nanoparticles: gold nanoparticles and single-wall
carbon nanotubes.
First, they injected mice with the some of the nanoparticles. To
see the nanoparticles, they used a special microscope that the
group had adapted to view anesthetized mice exposed to laser light.
The researchers could see that the nanoparticles migrated to the
liver, where they were processed for excretion.
Using a microscope they modified to detect Raman nanoparticles, the
team was able to see targets on a scale 1,000 times smaller than
what is now obtainable by the most precise fluorescence imaging
using quantum dots.
When adapted for human use, they said, the technique has the
potential to be useful during surgery, for example, in the removal
of cancerous tissue. The extreme sensitivity of the imager could
enable detection of even the most minute malignant tissues.
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[32]Fermi paradox, metamaterials, dark matter, recent science and advanced
aliens fading into the background
Traditional view of a [33]Dyson's sphere. Metamaterials could mask and
alter the observable signature and alter the interaction with
magnetism and the spectrum of space.
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The theory of dark matter is that 85-90% of the mass in the universe
is dark and does interact with the electromagnetic force.
Recently [40]there has been the design of metamaterials for magnetic
shielding/invisibility Previously there has been work and designs for
metamaterial to move microwaves, visible light and other wavelengths
around a shielded region. There has also been recent progress [41]on
direct conversion of radiation into electricity and the highly
efficient conversion of heat into electricity.
Scientists could use the metamaterial as a building block for a
magnetic invisibility cloak. Such a cloak could hide magnetism by
guiding an applied magnetic field around a cloaked region.
An advanced civilization could create a Dyson shell with metamaterials
on the outside for guiding light, heat and magnetism around the shell
[Dyson shell is converting all of the planets in a solar system into
solar collecting satellites that orbit the star at about the distance
of the earth. The structure lets you use all the solar energy of the
star which would be over a trillion times more energy that our
civilization uses]. Their shell would then have minimal interation
with light and magnetism.
[42]I had previous postings on the Fermi Paradox.
My speculation about technology and aliens is that we do not know what
civilizations with technology able to explore the galaxy would be
using. The Fermi paradox itself is based about speculations about
aliens.
Some the Fermi speculation is on dyson spheres and dyson shells
(visible megastructures) or visitations to our world. The
megastructures might not be the easiest things to spot. They might
look like some large infrared source about the size of earth's orbit.
Light would all be captured. Plus we are now learning how to convert
heat to electricity in a very efficient way. A highly advanced
civilization could be so efficient that they fade into the background
of space.
We could be way off base trying to predict what a civilization
hundreds, thousands or millions of years more technologically advanced
than us would be doing.
Rolling back a few hundred years. An advanced civilization would be
burning all of the forests for wood fuel or the new coal etc...
A bit before that an advanced civilization would be breeding and
domesticating bigger animals and making sailing ships with 100 to 1000
sails.
Really advanced aliens could have some kind of controlled big bangs.
Some high density pocket universes for power sources or they can leave
this universe/dimension and travel to or make their own more
productive places. People have talked about wormholes for possibly
traveling within our universe but that kind of control of space and
time means they could make their own dimensional places. I am not
saying that this scenario is likely but we do not know that the dyson
sphere/shell scenario or the Jupiter brain scenarios are the high
probability end state technology version either.
So looking on planets and around stars could be like primitives
looking into the best caves and wondering where the advanced people
are. Cave and tree dwelling was common 100,000 years ago. Projecting
out another 100,000 years in tech development is even more futile.
Plus with accelerating tech even projecting out 50-200 years is very,
very difficult.
Many people have an over-estimation of how much we have seen with
astronomy.
Up until a decade or so ago humanity had not detected the wobbles in
nearby stars caused by extrasolar planets. Up until that point planets
around other stars was speculation. Up until the recent discoveries it
was assumed that those planets would also have circular orbits like
most of the planets in our system. Now the feeling is that
non-circular orbits are more common.
If a dyson shell or sphere obscured a star then it is not like we
would like in that area and say that a star was missing. There might
be some difficult to detect infrared smudge. There are large voids in
space without visible stars or galaxies. One is a [43]billion light
years across. We do not how that happened or if the stars and galaxies
in there are just more sparse and difficult to see. Until now, optical
surveys have found no voids larger than 80 megaparsecs wide - making
the new hole 40 times larger in volume than the previous record
holder. So there are plenty of gaps in our observations.
Our observations of other galaxies is pathetic. It was not until Edwin
Hubble in the early 1920s using a new telescope that it was determined
whether some nebula were galaxies. He was able to resolve the outer
parts of some spiral nebulae as collections of individual stars and
identified some Cepheid variables, thus allowing him to estimate the
distance to the nebulae: they were far too distant to be part of the
Milky Way. In 1936 Hubble produced a classification system for
galaxies that is used to this day, the Hubble sequence.
Beginning in the 1990s, the Hubble Space Telescope yielded improved
observations. Among other things, it established that the missing dark
matter in our galaxy cannot solely consist of inherently faint and
small stars. The Hubble Deep Field, an extremely long exposure of a
relatively empty part of the sky, provided evidence that there are
about 125 billion galaxies in the universe.
But those galaxies of billions and trillions of stars are smudges. We
can say practically nothing about the composition of those smudges. We
can now only determine what is or is not a galaxy based on redshift
and pulsars to determine distance. If we now know whether some
galaxies have a certain order of redshift, this tells us what about
whether there is an advanced civilization inside. If an advanced
civilization tore apart their own galaxy and remade it into something
else, then how we would know that we should be seeing a galaxy where
there is none now. If they did this in the two million years but are
not in our galaxy then we would not have any light to observe from
this event. If they did it within the last 100 million years but are
not in our supercluster of galaxies then again we would have no light
for those events.
Our own Milky way galaxy was recently found to be [44]twice as fat as
we thought. (12000 light years instead of 6000 light years.)
The Andromeda galaxy in 2007 was found to be [45]five times bigger
than previously thought.
From our observation, we can not tell what is or is not inhabited. We
cannot tell what is or is not natural. We can make assumptions, but we
do not know. If another civilization was to look at our solar system
and all they could get was the light from our star and maybe if they
were had good telescopes whether or not Jupiter passed in front of our
star, what could they say about life on earth which they do not know
is there ? What could they say if we had molecular nanotechnology and
super AI and fusion power and one hundred times the population and
terraformed Mars and Venus and have spaceships flying around the solar
system. Looks the same still a star.
What if they were looking from a five thousand light years away at a
shot of tens of millions of stars. If we had erected a dyson shell and
now our star is obscured. Would there picture of ten million stars be
different from ten million + 1 stars ? Would they be able to determine
from gravitational tracking that there was an obscured star ?
How about if they were looking at the galaxy ? If they are inside the
Milky Way and do not know whether there are 100 billion stars or 2
trillion stars then what can they say about life, even advanced life ?
What if those aliens had only indirectly detected 200 planets and most
that are 10 times the size of Jupiter or bigger ? What if there radio
telescopes could not pickup radio signals from an equivalent
civilization because the transmissions become attenuated and fade into
the background. What if the civilization is just now still finding
planets larger than Pluto in their own solar system and may not have
spotted 100 objects of the size of the moon to the Pluto or bigger.
FURTHER READING
[46]A d.c. magnetic metamaterial: Nature Materials
Electromagnetic metamaterials are a class of materials that have
been artificially structured on a subwavelength scale. They are
currently the focus of a great deal of interest because they allow
access to previously unrealizable properties such as a negative
refractive index. Most metamaterial designs have so far been based
on resonant elements, such as split rings, and research has
concentrated on microwave frequencies and above. Here, we present
the first experimental realization of a non-resonant metamaterial
designed to operate at zero frequency. Our samples are based on a
recently proposed template for an anisotropic magnetic metamaterial
consisting of an array of superconducting plates. Magnetometry
experiments show a strong, adjustable diamagnetic response when a
field is applied perpendicular to the plates. We have calculated
the corresponding effective permeability, which agrees well with
theoretical predictions. Applications for this metamaterial may
include non-intrusive screening of weak d.c. magnetic fields.
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[63]Gene Therapy Breakthrough- Three Micro RNA inhibition injections reduces
cholesterol 30%, 2013 for human use
[64]Two forms of RNA either boost or suppress protein production, and
scientists have in recent years discovered this system is central to a
range of illnesses, including cancers, viral infections,
cardiovascular disease and neurological disorders.
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Previous attempts to manipulate this process have failed because the
drug molecules used were too large to get to the target cells. Now
scientists at [71]Santaris Pharma have developed smaller compounds
that can cross cell membranes and intercept the microRNA molecules
that usually put a brake on protein production.
[72]LNA-mediated microRNA silencing in non-human primates.
MicroRNAs (miRNAs) are small regulatory RNAs that are important in
development and disease and therefore represent a potential new
class of targets for therapeutic intervention. Despite recent
progress in silencing of miRNAs in rodents, the development of
effective and safe approaches for sequence-specific antagonism of
miRNAs in vivo remains a significant scientific and therapeutic
challenge. Moreover, there are no reports of miRNA antagonism in
primates. Here we show that the simple systemic delivery of a
unconjugated, PBS-formulated locked-nucleic-acid-modified
oligonucleotide (LNA-antimiR) effectively antagonizes the
liver-expressed miR-122 in non-human primates. Acute administration
by intravenous injections of 3 or 10 mg kg-1 LNA-antimiR to African
green monkeys resulted in uptake of the LNA-antimiR in the
cytoplasm of primate hepatocytes and formation of stable
heteroduplexes between the LNA-antimiR and miR-122. This was
accompanied by depletion of mature miR-122 and dose-dependent
lowering of plasma cholesterol. Efficient silencing of miR-122 was
achieved in primates by three doses of 10 mg kg-1 LNA-antimiR,
leading to a long-lasting and reversible decrease in total plasma
cholesterol without any evidence for LNA-associated toxicities or
histopathological changes in the study animals. Our findings
demonstrate the utility of systemically administered LNA-antimiRs
in exploring miRNA function in rodents and primates, and support
the potential of these compounds as a new class of therapeutics for
disease-associated miRNAs.
Mice on a high fat diet were given three injections of a drug to block
miRNA-122, a compound in the liver that controls cholesterol levels.
Those given the highest dose had 30 per cent lower cholesterol levels
than those given placebo injections, and the effects lasted three
weeks after the last injection.
Laboratory tests also showed that blocking miRNA-122 also prevented
the hepatitis C virus replicating. Human trails of a drug to treat
hepatitis C will begin next year and scientists are using the method
to develop a treatment to combat blood cancers.
Santaris predicts new therapies will be ready for use by patients
within five years if trials go well.
Santaris Pharma is preparing to advance its first LNA-antimiR
compound, targeting miR-122, into human clinical testing in the first
half of 2008.
FURTHER READING
[73]Safer and more precise methods of targeting gene therapy are being
made with synthetic zinc fingers.
[74]Researchers have figured out the real problem with a common gene
therapy delivery system the adenovirus type 5. Adenovirus consists of
three major proteins - fiber, penton and hexon. Previously researchers
thought the fiber protein was the problem. New research indicates it
is the hexon. Now by modifying the hexon they can make adenovirus
delivered gene therapy safe.
"Now that we have learned the mechanism that an adenovirus uses we
could modify that process by genetically engineering the virus, to
improve uptake into several cell types, including stem cells," says
Dr. Napoli.
[75]There has also been progress in using gene therapy to treat brain
cancer.
[76]Safe and effective gene therapy or drugs that safely target
genetic effects could be used to safely boost muscle mass by four
times. This could make people stronger and healthier. Better weight
control with more muscle that burns excess fat. 2012-2016 seems to be
the likely timeframe when these procedures start making a big societal
impact. It could happen sooner and more could happen later, but that
seems to be the time when more people will realize that a new age is
upon the world.
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More Recent Articles
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nanotubes and a separate new approach to thermoelectrics
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----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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