[tt] 'Hot' ice could lead to medical device

[Eugen Leitl]

http://physorg.com/news109953386.html

'Hot' ice could lead to medical device

Doctoral student Alexander Wissner-Gross (above) and Efthimios Kaxiras,
Gordon McKay Professor of Applied Physics, have shown that treated diamond
coatings can keep water frozen at body temperature. Photo: Stephanie
Mitchell/Harvard University

Harvard physicists have shown that specially treated diamond coatings can
keep water frozen at body temperature, a finding that may have applications
in future medical implants.

Doctoral student Alexander Wissner-Gross and Efthimios Kaxiras, physics
professor and Gordon McKay Professor of Applied Physics, spent a year
building and examining computer models that showed that a layer of diamond
coated with sodium atoms will keep water frozen up to 108 degrees Fahrenheit.

In ice, water molecules are arranged in a rigid framework that gives the
substance its hardness. The process of melting is somewhat like a building
falling down: pieces that had been arranged into a rigid structure move and
flow against one another, becoming liquid water.

The computer model shows that whenever a water molecule near the
diamond-sodium surface starts to fall out of place, the surface stabilizes it
and reassembles the crystalline ice structure.

Simulations show that the process works only for layers of ice so thin
they’re just a few molecules wide — three nanometers at room temperature and
two nanometers at body temperature. A nanometer is a billionth of a meter.

The layer should be thick enough to form a biologically compatible shield
over the diamond surface and to make diamond coatings more useful in medical
devices, Wissner-Gross said.

The work is not the first showing that water can freeze at high temperatures.
Dutch scientists had shown previously that ice can form at room temperature
if placed between a tiny tungsten tip and a graphite surface. Kaxiras and
Wissner-Gross’s work shows that ice can be maintained over a large area at
body temperature and pressure.

Device manufacturers have been considering using diamond coatings in medical
implants because of their hardness. Concerns have been raised, however,
because the coatings are difficult to get absolutely smooth, abrasion of the
tissue surrounding the implant could result, and that diamond might have a
higher chance of causing blood clots than other materials.

Wissner-Gross said a two-nanometer layer of ice would just fill the pits in
the diamond surface, smoothing it out and discouraging clotting proteins from
attaching to the surface.

“It should be just soft enough and water-friendly enough to smooth out
diamond’s disadvantages,” Wissner-Gross said.

Wissner-Gross and Kaxiras are planning experiments to confirm the
computerized findings in the real world. Wissner-Gross said they expect
results within a year.

“We’re reasonably confident we’ll be able to realize the effect
experimentally,” Wissner-Gross said.

Wissner-Gross, who has been a doctoral student at Harvard since 2003, said
the research grew out of an interest in the physical interaction of
nanostructured surfaces with molecules that are biologically relevant, such
as water. Diamond films are growing cheaper, Wissner-Gross said, and as their
cost declines the array of possible uses of the material grows wider.

“We both had this notion that it would be very interesting to combine theory
with respect to diamond surfaces with what’s going on in cryobiology,”
Wissner-Gross said. “We were thinking about how we could leverage this
long-term trend [of declining prices] to do something interesting in the
medical field.”

The work has won Wissner-Gross the 2007 Dan David Prize Scholarship from Tel
Aviv University and the 2007 Graduate Student Silver Award from the Materials
Research Society.

Wissner-Gross, who expects to graduate in June 2008, said he plans to
continue work not only on this project, but on other efforts concerning the
physics of surfaces that have novel properties.

Source: Harvard University, by Alvin Powell