[tt] advanced nanotechnology - 5 new articles
Eugen Leitl
<eugen at leitl.org> on
Mon Oct 8 11:53:57 UTC 2007
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Subject: advanced nanotechnology - 5 new articles
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"[2]advanced nanotechnology" - 5 new articles
1. [3]Hillary Clinton on Science
2. [4]Skewing the odds for possible superior genetic results
3. [5]Pro-nuclear ruling in the USA
4. [6]Human embryonic stem cells remain embryonic because of
epigenetic factors
5. [7]Superstrength polymers using layer by layer assembly
6. [8]More Recent Articles
7. [9]Search advanced nanotechnology
[10]Hillary Clinton on Science
[11]Hillary Clinton has given a speech that outlines her position on
stem cells (for lifting research bans), space (more for space science
not for manned Mars and moon), and for having directors of science
related programs ensure that politics is kept out of science
decisions.
This is relevant because Hillary Clinton is currently leading the
democratic candidates in polling by a wide margin, she has the most
funds raised of any candidate Republican or Democrat, and she has what
is widely acknowledged as the best and most disciplined political
machine.
Not really going out on much of a limb: I predict that she will win
the US presidency in 2008.
[12]Related to this is a prediction market tracking indicating 58-60%
chances of a Democrat becoming president in 2008
[13]At tradesports on Oct 5, 2007, Hillary will win president is 42.7%
They have Obama at 8.2%, Al Gore at 7.7% and Edwards at 2.6%. If we
presume that Hillary is a Democratic nomination lock then she would
move to 61%.
I support space development, but I do not mind the fact that she will
probably cut the manned Mars and Moon programs. The programs, as they
are currently planned, are misguided.
1) The current human Moon and Mars plan look like a lot money for not
much return
The total funding of [14]Project Constellation through 2025,
inflation-adjusted and without any other increases to NASA's budget,
is estimated at $210 billion; the ESAS estimates the cost of the
program through that date at being only $7 billion more, at $217
billion.
[15]Project Constellation is a NASA program to create a new generation
of spacecraft for human spaceflight, consisting primarily of the Ares
I and Ares V launch vehicles, the Orion crew capsule, the Earth
Departure Stage and the Lunar Surface Access Module. These spacecraft
will be capable of performing a variety of missions, from Space
Station resupply to lunar landings. so the $210-217 billion estimates
is just the start and does not get the humans to Mars part of the
plan.
[16]The International space Station was also a lot of money
($100+billion) for very little return. So the purpose of space station
resupply is not useful either.
All of the pieces pretty much duplicate existing rocket capability.
2) Nasa should not build and operate the hardware and the missions.
The US government does not build the highway system, and the cars and
operate all of the vehicles. Government shoulder the risky development
of new technology. Like the first two nuclear propulsion rockets or
super-ion drive tugs, then license the technology to private industry.
3) We could start paying just for lunar and orbital development
without this hardware. If we make new space hardware then it should be
for hardware that really makes a substantial improvement in cost and
performance.
As I have noted [17]in my proposed plan to win the Google lunar
landing challenge, Nasa could use existing rockets and launch large
robotic missions to the Moon starting in 2008-2012.
-Build a large lunar lander (lunar orbit to the surface), repeating
old tech but scaled up
-Build the earth orbit to lunar transfer tug
-Build the robots and systems that you want to land on the moon.
-Use an existing rocket to take it to earth orbit, with about 20 tons
-Use low energy transfer to get it from earth orbit to the moon, takes
5 months but uses very little fuel by weight of the vehicle. 10% of
the vehicle weight from earth orbit
-Use the large lunar lander to deliver 5-15 tons of robots and
equipment to the moon with each $70-200 million trip.
Using about $3 billion per year. There could be six missions to the
moon each year with $500 million per mission. $200 million for the
trip. $300 million for the gear and the mission.
The purpose would be to land things to build up what would become
permanent infrastructure on the moon and in earth and lunar orbit.
Power generation systems and systems for processing material and
building facilities (telescopes, pre-deployed moon bases.)
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[31]Skewing the odds for possible superior genetic results
[32]there has been a fair amount of discussion about the idea of
genetically screening 1000 eggs or embryos in order to get genetically
gifted populations (1000 Einsteins).
[33]My past cognitive enhancement survey from 2006 for using drugs,
genetics, computers and other methods for cognitive enhancement. It is
not all about genes.
Not all of the genes are known, but there is growing base of knowledge
of positive and negative genes for intelligence. We are getting a
growing ability to successfully shift the odds of desired genetic
results across populations. There is not really genetic determinism
but genetics affecting the likelihood of good or bad results.
[34]List of notable human genes
[35]CHRM2 positive correlation with increased intelligence
[36]Recessive alleles around at about 325 loci increase mental
retardation
[37]Mental retardation genes AGTR2
[38]ZDHHC9 gene found (severe mental retardation)
[39]Intelligence enhancement genes discussed at Futurepundit.com
[40]Scientists reverse mental retardation in mice (FMR1, FRMP)
[41]Proper Training is very important to take advantage of genetic
abilities.
Deliberate practice entails more than simply repeating a task --
playing a C-minor scale 100 times, for instance, or hitting tennis
serves until your shoulder pops out of its socket. Rather, it
involves setting specific goals, obtaining immediate feedback and
concentrating as much on technique as on outcome.
Their work, compiled in the "Cambridge Handbook of Expertise and
Expert Performance," a 900-page academic book makes a rather
startling assertion: the trait we commonly call talent is highly
overrated. Or, put another way, expert performers -- whether in
memory or surgery, ballet or computer programming -- are nearly
always made, not born.
The odds can be shifted.
It is like poker. For cards it is like picking starting hands based on
seeing 2 out of seven cards (selecting based on known information the
starting embryo) and then also being given 1 redraw (genetic
engineering after birth)
Also, with epigenetic control or RNA interference one could inactivate
one or two of the cards that is known to be bad. You keep skewing
things towards superior hands.
The more we know then the more we can shift the results and increase
the odds and the occurrence of high intelligence.
If we reduce by 50% of those with IQ below 100 and double those with
IQ above 150.
then the percentage of people who were effected by the procedures has
3 times the percentage occurrence of people with IQ above 150.
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[55]Pro-nuclear ruling in the USA
[56]There has been an interpretation ruling on loan guarantees for
100% of the loan to a maximum of 80% of the total project for carbon
dioxide reducing energy projects The loan guarantees make nuclear
energy the cheapest option for energy. It pretty much guarantees that
all 30 nuclear reactors that are in the planning stages in the USA
will be built.
If a reasonable [57]climate change bill is passed (likely in 2009)
then the combination will cause a boom in nuclear power building in
the United States. The amount of nuclear power would be projected to
triple by 2030. 100-150 of the new larger reactors would be the
primary source of any new power needs (along with more wind, solar and
biomass and conservation and efficiency). The climate change bill will
likely ratchet up the cost of coal plants and cause them to be
shutdown and replaced over 20-30 year timeframe.
FURTHER READING
[58]Thermoelectronics for more energy efficiency
[59]Electric bikes and scooters in China and India key for clean
global transportation.
[60]Cars that are more fuel efficient than the Toyota Prius
[61]Tracking increased orders for nuclear power around the world
[62]EIA computational analysis of the projected impact of one of the
climate bills
[63]Increasing the power output of existing nuclear power plants
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[77]Human embryonic stem cells remain embryonic because of epigenetic
factors
[78]A human embryonic stem cell is reined in - prevented from giving
up its unique characteristics of self-renewal and pluripotency - by
the presence of a protein modification that stifles any genes that
would prematurely instruct the cell to develop into heart or other
specialized tissue.
Thanks to the simultaneous presence of different protein
modifications, stem cells are primed and poised, ready to develop
into specialized body tissue, Singapore scientists reported in last
month's issue of the journal Cell Stem Cell.
The molecules central to this balancing act, H3K4me3 and H3K27me3,
are among the so-called epigenetic modifications that influence the
activity patterns of genes in both human embryonic stem (ES) cells
and mature human adult cells.
His GIS colleague, Wei Chia-Lin, Ph.D., who headed the Singapore
research team, said, "This study demonstrates the power of a whole
genome and robust sequencing technology, when applied in the
epigenetic analysis of ES cells, can reveal features of the genomes
that were not previously appreciated. The new knowledge and target
candidate genes resulted from such unbiased study are ultimately
important for researchers to understand the fundamental nature of
stem cell proliferation and differentiation."
Drs. Wei and Ng and the other researchers used cutting-edge
technologies developed at GIS, to sequence, or decipher, the DNA of
human ES cells. With the sequence data in hand, the scientists were
able to categorize the genes into three groups, each modified by
different combinations of the two epigenetic markers.
The researchers discovered that the majority of the regions in the
genome harbor active histone marks that act as sign posts and allow
cells to quickly find genes "to turn on" or activate them.
Identifying the locations of these genomic signposts will also be
crucial for discovering human genes that are important for
different functions in ES cells.
Of the two epigenetic markers, H3K4me3 was found to be the most
prevalent - the scientists reported and noted that it occurs near
the DNA areas that are promoters of two-thirds of human genes. Of
the 17,469 nonredundant unique human genes that the scientists
sequenced, 68% contained H3K4me3, and only 10% contained
overlapping H3K27me3.
More information about epigenetic modifications:
In living cells, DNA is packaged along with histone proteins, which
are chief protein components that act as spools around which DNA
winds. The histone proteins are decorated with different marks,
which can affect the various activities of the modified DNA such as
transcription, gene silencing, imprinting and replication. Such
marks key roles in the process of cellular differentiation,
allowing cells to maintain different characteristics despite
containing the same genomic material. While different cells can
have identical genetic DNA sequences, their characteristics and
differentiation patterns are influenced by the different marks on
the histone proteins. Therefore, histone marks represent an
epigenetic marker or code that can be used by the cells to expand
their plasticity and complexity.
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epigenetic factors'
[92]Superstrength polymers using layer by layer assembly
[93]Superstrong transparent plastic has been made using superior
layering technique.
[94]Before this process load transfer has been quite ineffective at
loadings more than 5-10%.
After that the mechanical properties of regular composites actually
start degrading with increasing portion of inorganic filler.
Kotov's findings indicate that organization of the composite and
tuning of molecular interactions between clay and polymer can give
almost ideal stress transfer at loadings as high as 50-60%. This
can be achieved with a technique called layer-by-layer (LBL)
assembly, which makes clay sheets to become oriented parallel to
the substrate. Kotov explains that the LBL process is based on
sequential adsorption of nanometer-thick monolayers of oppositely
charged compounds (e.g. polyelectrolytes, charged nanoparticles,
biological macromolecules, etc.) to form a multilayered structure
with nanometer-level control over the architecture. Kotov points
out that all polymer chains poorly bound to clay sheet are removed
during their LBL assembly process.
"We solved the problem of load transfer quite well for clay sheets"
says Kotov. "This is very encouraging. Potentially it can be solved
for carbon nanotubes and other nanostructures as well." Specific
applications for these clay composites are, of course, in military
vehicles but also in aerospace and the automotive industry.
Basically, these materials could be considered for components in
unmanned aerial vehicles and electronic devices that are exposed to
extreme performance conditions. "The future directions of this
research will be increasing not only the strength and stiffness but
also the strain of the composites, which will yield the toughness"
says Kotov. "Having high strains would truly result in 'plastic
steel.' We are also working on the better understanding the
nanomechanics of these materials.
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More Recent Articles
* [108]thermoelectronics technology in depth from recent dept of
energy conference. Imminent use to make better refriderators,
quieter submarines, fuel efficient cars, trucks and industrial
plants. The overall economy could be 10-18% more energy efficient
by 203 [del.icio.us]
* [109]Thermoelectronics for cars, trucks, submarines,
refridgerators and more
* [110]Carnival of Space Week 23
* [111]Thermoelectronic potential and status
* [112]$100 genome sequencing possible within 5 years, plus links to
all of the intermediate and competing methods for reducing
sequencing costs [del.icio.us]
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88. http://www.feedblitz.com/f/f.fbz?Search=64651;171888;gene%20sequencing,dna,future,medicine,epigenetics,stem%20cells;Human%20embryonic%20stem%20cells%20remain%20embryonic%20because%20of%20epigenetic%20factors;92276
89. http://www.feedblitz.com/related.asp?http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165564365/human-embryonic-stem-cells-remain.html
90. http://www.talkr.com/app/text_to_audio.app?feed_url=http%3a%2f%2ffeeds.feedburner.com%2fblogspot%2fadvancednano&permalink=http%3a%2f%2ffeeds.feedburner.com%2f~r%2fblogspot%2fadvancednano%2f~3%2f165564365%2fhuman-embryonic-stem-cells-remain.html&src=5
91. LYNXIMGMAP:file://localhost/tmp/mutt.html#outbrainMap_64651_3
92. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165544233/superstrength-polymers-using-layer-by.html
93. http://technology.newscientist.com/article/dn12736-motherofpearl-inspires-superstrong-plastic.html
94. http://www.nanowerk.com/spotlight/spotid=2827.php
95. http://feeds.feedburner.com/~f/blogspot/advancednano?a=j1qCKvD9
96. http://feeds.feedburner.com/~f/blogspot/advancednano?a=3CZk8iQm
97. http://feeds.feedburner.com/~f/blogspot/advancednano?a=T15Bxl82
98. http://feeds.feedburner.com/~f/blogspot/advancednano?a=38JDWmLi
99. http://feeds.feedburner.com/~f/blogspot/advancednano?a=adGvTNFW
100. http://feeds.feedburner.com/~f/blogspot/advancednano?a=vf638YKc
101. http://feeds.feedburner.com/~f/blogspot/advancednano?a=WNn4qoUz
102. http://feeds.feedburner.com/~f/blogspot/advancednano?a=qg6l1Pkk
103. http://www.feedblitz.com/f/f.fbz?Fwd2FriendEdit=64651;171888;http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165544233/superstrength-polymers-using-layer-by.html;Superstrength%20polymers%20using%20layer%20by%20layer%20assembly;92276
104. http://www.feedblitz.com/f/f.fbz?Search=64651;171888;nanomaterials,future,carbon%20nanotubes;Superstrength%20polymers%20using%20layer%20by%20layer%20assembly;92276
105. http://www.feedblitz.com/related.asp?http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165544233/superstrength-polymers-using-layer-by.html
106. http://www.talkr.com/app/text_to_audio.app?feed_url=http%3a%2f%2ffeeds.feedburner.com%2fblogspot%2fadvancednano&permalink=http%3a%2f%2ffeeds.feedburner.com%2f~r%2fblogspot%2fadvancednano%2f~3%2f165544233%2fsuperstrength-polymers-using-layer-by.html&src=5
107. LYNXIMGMAP:file://localhost/tmp/mutt.html#outbrainMap_64651_4
108. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165423140/thermoelectronics-for-cars-trucks.html
109. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165423140/thermoelectronics-for-cars-trucks.html
110. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/165041152/carnival-of-space-week-22.html
111. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/164892209/thermoelectronic-potential-and-status.html
112. http://feeds.feedburner.com/~r/blogspot/advancednano/~3/163922062/100-human-genome-project.html
113. http://tagline.feedblitz.com/nfc?affid=10059&sender=cf515ead64587146fb6815a2a013d226,feedblitz.com&rcpt=8da0e5c5ebdabb2bd85a8a5d3a603a7c,leitl.org&ranstr=bb109100-73eb-11dc-b0c9-003005ce&group=64651
114. http://www.feedblitz.com/f/f.fbz?EmailRemove=_Mjk4NzI1M3w2NDY1MXxldWdlbkBsZWl0bC5vcmd8OTIyNzY=_
115. http://www.feedblitz.com/f/f.fbz?Subscriptions=64651
116. http://www.feedblitz.com/f
117. http://www.feedblitz.com/f/f.fbz?EmailRemove=_Mjk4NzI1M3x8ZXVnZW5AbGVpdGwub3JnfDkyMjc2_
118. http://www.feedblitz.com/
119. http://www.feedblitz.com/
----- End forwarded message -----
--
Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
______________________________________________________________
ICBM: 48.07100, 11.36820 http://www.ativel.com http://postbiota.org
8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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