[tt] [Synthetic Biology] Executable cell biology

[Eugen Leitl]

----- Forwarded message from gajinder singh <gajinder_pal_singh at yahoo.co.uk> -----

From: gajinder singh <gajinder_pal_singh at yahoo.co.uk>
Date: Tue, 13 Nov 2007 09:41:13 +0000 (GMT)
To: discuss at syntheticbiology.org
Subject: [Synthetic Biology] Executable cell biology

This might be useful.



http://www.nature.com/nbt/journal/v25/n11/abs/nbt1356.html

Nature Biotechnology 25, 1239 - 1249 (2007)
Published online: 7 November 2007 |
doi:10.1038/nbt1356

Executable cell biology

Jasmin Fisher1,2 & Thomas A Henzinger2,3
Abstract

Computational modeling of biological systems is
becoming increasingly important in efforts to better
understand complex biological behaviors. In this
review, we distinguish between two types of biological
models—mathematical and computational—which differ in
their representations of biological phenomena. We call
the approach of constructing computational models of
biological systems 'executable biology', as it focuses
on the design of executable computer algorithms that
mimic biological phenomena. We survey the main
modeling efforts in this direction, emphasize the
applicability and benefits of executable models in
biological research and highlight some of the
challenges that executable biology poses for biology
and computer science. We claim that for executable
biology to reach its full potential as a mainstream
biological technique, formal and algorithmic
approaches must be integrated into biological
research. This will drive biology toward a more
precise engineering discipline.
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