[tt] [Synthetic Biology] data inheritence in B. subtilis

[Eugen Leitl]

----- Forwarded message from Markus Schmidt <markus.schmidt at id-c.org> -----

From: Markus Schmidt <markus.schmidt at id-c.org>
Date: Sat, 26 May 2007 11:34:09 +0200
To: discuss at syntheticbiology.org
Subject: [Synthetic Biology] data inheritence in B. subtilis
X-Mailer: Apple Mail (2.752.2)


Here is an article on storing data in the Bacillus subtilis genome in  
a robust way to counter data loss by mutation:

Alignment-Based Approach for Durable Data Storage into Living Organisms
Biotechnol. Prog. 2007, 23, 501-505


http://pubs.acs.org/cgi-bin/sample.cgi/bipret/2007/23/i02/pdf/ 
bp060261y.pdf
or
http://pubs.acs.org/cgi-bin/sample.cgi/bipret/2007/23/i02/html/ 
bp060261y.html

Abstract:
The practical realization of DNA data storage is a major scientific  
goal. Here we introduce a
simple, flexible, and robust data storage and retrieval method based  
on sequence alignment of
the genomic DNA of living organisms. Duplicated data encoded by  
different oligonucleotide
sequences was inserted redundantly into multiple loci of the Bacillus  
subtilis genome. Multiple
alignment of the bit data sequences decoded by B. subtilis genome  
sequences enabled the retrieval
of stable and compact data without the need for template DNA, parity  
checks, or error-correcting
algorithms. Combined with the computational simulation of data  
retrieval from mutated message
DNA, a practical use of this alignment-based method is discussed.


Markus






*----------------------------------------------------------------------- 
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Dr. Markus Schmidt
Organisation for International Dialogue and Conflict Management
Biosafety Working Group
Abt-Karlg. 19/21, 1180 Vienna, Austria
NEW MOBILE: +43 660 6856623
www.idialog.eu
email: markus.schmidt at idialog.eu or
markus.schmidt at id-c.org
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Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
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