[neuro] [Comp-neuro] Neural modeling article on encoding and retrieval of a hippocampal CA1 microcircuit

[Eugen Leitl]

----- Forwarded message from "Cutsuridis, Vassilis" <vcu at cs.stir.ac.uk> -----

From: "Cutsuridis, Vassilis" <vcu at cs.stir.ac.uk>
Date: Mon, 27 Jul 2009 16:36:01 +0300
To: connectionists at cs.cmu.edu, comp-neuro at neuroinf.org
Cc: 
Subject: [Comp-neuro] Neural modeling article on encoding and retrieval of a
	hippocampal CA1 microcircuit
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   The following article about memory storage and retrieval of
   a hippocampal microcircuit is available
   at [1]http://www.cs.stir.ac.uk/~vcu:

   Cutsuridis, V., Cobb, S., Graham B.P.

   Encoding and retrieval in the hippocampal CA1 microcircuit model.

   Hippocampus, in press.
   ABSTRACT

   It has been proposed that the hippocampal theta rhythm (47 Hz) can
   contribute to memory formation by separating encoding (storage) and
   retrieval of memories into different functional half-cycles (Hasselmo
   et al. (2002) Neural Comput 14:793817). We investigate, via computer
   simulations, the biophysical mechanisms by which storage and recall of
   spatio-temporal input patterns are achieved by the CA1 microcircuitry.
   A model of the CA1 microcircuit is presented that uses biophysical
   representations of the major cell types, including pyramidal (P) cells
   and four types of inhibitory interneurons: basket (B) cells, axoaxonic
   (AA) cells, bistratified (BS) cells, and oriens lacunosum-moleculare
   (OLM) cells. Inputs to the network come from the entorhinal cortex
   (EC), the CA3 Schaffer collaterals, and medial septum. The EC input
   provides the sensory information, whereas all other inputs provide
   context and timing information. Septal input provides timing
   information for phasing storage and recall. Storage is accomplished
   via a local STDP mediated hetero-association of the EC input pattern
   and the incoming CA3 input pattern on the CA1 pyramidal cell target
   synapses. The model simulates the timing of firing of different
   hippocampal cell types relative to the theta rhythm in anesthetized
   animals and proposes experimentally confirmed functional roles for the
   different classes of inhibitory interneurons in the storage and recall
   cycles (Klausberger et al. (2003)Nature 421:844848; Klausberger et al.
   (2004) Nat Neurosci 7:4147). Measures of recall performance of new and
   previously stored input patterns in the presence or absence of various
   inhibitory interneurons are used to quantitatively test the
   performance of our model. Finally, the mean recall quality of the CA1
   microcircuit is tested as the number of stored patterns is increased.



   Key Words: CA1 microcircuit model; storage and recall; pyramidal cell;
   basket cell; bistratified cell; OLM cell; axo-axonic cell; STDP

References

   Visible links
   1. http://www.cs.stir.ac.uk/~vcu

   Hidden links:
   2. http://www.cs.stir.ac.uk/%AC

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Eugen* Leitl <a href="http://leitl.org">leitl</a> http://leitl.org
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